C₁₆H₁₃N₃O

Base Information

• Chemical Name: C₁₆H₁₃N₃O
• CAS No.: 1279722-80-3
• Molecular Formula: C₁₆H₁₃N₃O
• Molecular Weight: 263.299
• Mol file: 1279722-80-3.mol

Synonyms:

Chemical Property of C₁₆H₁₃N₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₃N₃O

There total 3 articles about C₁₆H₁₃N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Br(1-)*C27H24OP(1+) (1279723-31-7) + 2-azidobenzaldehyde (16714-25-3) → C16H13N3O + C16H13N3O (1279722-80-3)

Guidance literature:

Br^(1-)*C₂₇H₂₄OP⁽¹⁺⁾; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

2-azidobenzaldehyde; In tetrahydrofuran; hexane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201006917

Reference yield:

4-bromo-3,4-dihydro-2H-chromene → C16H13N3O + C16H13N3O (1279722-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 16 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane; toluene; 2.1: Wittig reaction / 2.2: Wittig reaction;

DOI:10.1002/anie.201006917

Reference yield:

4-hydroxychroman (1481-93-2) → C16H13N3O + C16H13N3O (1279722-80-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen bromide / dichloromethane; water

2.1: toluene / 16 h / Inert atmosphere; Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With n-butyllithium; hydrogen bromide; In tetrahydrofuran; hexane; dichloromethane; water; toluene; 3.1: Wittig reaction / 3.2: Wittig reaction;

DOI:10.1002/anie.201006917

upstream raw materials:

Br^(1-)*C₂₇H₂₄OP⁽¹⁺⁾

2-azidobenzaldehyde

4-hydroxychroman