1-(((7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)((tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)cyclopropanol

Base Information

Chemical Name:1-(((7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)((tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)cyclopropanol
CAS No.:1380434-20-7
Molecular Formula:C₂₈H₃₇N₃O₅S
Molecular Weight:527.685
Hs Code.:

1-(((7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)((tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)cyclopropanol

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Chemical Property of 1-(((7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)((tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)cyclopropanol

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Technology Process of 1-(((7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)((tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)cyclopropanol

There total 6 articles about 1-(((7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)((tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)cyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₅₁N₃O₅SSi

: 1380434-20-7
1-(((7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)((tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)cyclopropanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm300259r

Reference yield:

: [2-methylthiopyrazolo[1,5-a]pyridin-3-yl]amine

: 1380434-20-7
1-(((7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)((tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)cyclopropanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C / Cooling with ice

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 - 50 °C

5.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

6.1: sodium tris(acetoxy)borohydride / tetrahydrofuran; acetic acid / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; barium hydroxide octahydrate; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; 3.1: Suzuki coupling;
DOI:10.1021/jm300259r

Reference yield:

: 63432-37-1
2-methylsulfanyl-3-nitropyrazolo[1,5-a]pyridine

: 1380434-20-7
1-(((7-(2,6-dimethoxy-4-(methoxymethyl)phenyl)-2-(methylthio)pyrazolo[1,5-a]pyridin-3-yl)((tetrahydro-2H-pyran-4-yl)methyl)amino)methyl)cyclopropanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; zinc / ethanol; water / 0.33 h / 80 °C

2.1: triethylamine / dichloromethane / 16 h / 20 °C / Cooling with ice

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 0.17 h / -78 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 - 50 °C

6.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

7.1: sodium tris(acetoxy)borohydride / tetrahydrofuran; acetic acid / 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; barium hydroxide octahydrate; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; triethylamine; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; 4.1: Suzuki coupling;
DOI:10.1021/jm300259r