N-[2-(dimethylamino)ethyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzamide

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Chemical Name:N-[2-(dimethylamino)ethyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzamide
CAS No.:1246433-97-5
Molecular Formula:C₂₅H₂₅N₇O
Molecular Weight:439.52
Hs Code.:

Synonyms:

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Chemical Property of N-[2-(dimethylamino)ethyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzamide

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Technology Process of N-[2-(dimethylamino)ethyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzamide

There total 6 articles about N-[2-(dimethylamino)ethyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201790-34-2
5-chloro-2-methoxy-4-(trimethylstannyl)pyridine

: 1246433-97-5
N-[2-(dimethylamino)ethyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: cesium fluoride; copper(l) iodide / N,N-dimethyl-formamide / 2 h / 125 °C / sealed tube; Microwave irradiation

2: potassium tert-butylate / palladium diacetate; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3: hydrogenchloride; acetic acid / water / 2 h / 140 °C / sealed tube; Microwave irradiation

4: triethylamine / pyridine / 2 h / 140 °C / Sealed tube; Microwave irradiation

5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 140 °C / sealed tube; Microwave irradiation; Inert atmosphere

6: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 140 °C / sealed tube; Microwave irradiation; Inert atmosphere

With hydrogenchloride; copper(l) iodide; potassium tert-butylate; caesium carbonate; acetic acid; triethylamine; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; pyridine; water; N,N-dimethyl-formamide;

Reference yield:

: 1201790-49-9
5'-chloro-2',4-dimethoxy-3,4'-bipyridin-2-amine

: 1246433-97-5
N-[2-(dimethylamino)ethyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / palladium diacetate; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2: hydrogenchloride; acetic acid / water / 2 h / 140 °C / sealed tube; Microwave irradiation

3: triethylamine / pyridine / 2 h / 140 °C / Sealed tube; Microwave irradiation

4: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 140 °C / sealed tube; Microwave irradiation; Inert atmosphere

5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 140 °C / sealed tube; Microwave irradiation; Inert atmosphere

With hydrogenchloride; potassium tert-butylate; caesium carbonate; acetic acid; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; pyridine; water;

Reference yield:

: 1201790-50-2
4,6-dimethoxy-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1246433-97-5
N-[2-(dimethylamino)ethyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; acetic acid / water / 2 h / 140 °C / sealed tube; Microwave irradiation

2: triethylamine / pyridine / 2 h / 140 °C / Sealed tube; Microwave irradiation

3: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 140 °C / sealed tube; Microwave irradiation; Inert atmosphere

4: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 140 °C / sealed tube; Microwave irradiation; Inert atmosphere

With hydrogenchloride; caesium carbonate; acetic acid; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; pyridine; water;