Technology Process of methyl 5-acetamido-1,4,7,8-tetra-O-acetyl-9-O-benzoyl-3,5-dideoxy-D-glycero-β-D-galacto-2-nonulopyranoside
There total 11 articles about methyl 5-acetamido-1,4,7,8-tetra-O-acetyl-9-O-benzoyl-3,5-dideoxy-D-glycero-β-D-galacto-2-nonulopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 88 percent / Et3N / acetonitrile / 1 h / -35 °C
2: 89 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 12.3 h / -10 °C
3: 77 percent / NaH, MgSO4 / CH2Cl2 / 10 h
4: 92 percent / 0.3M BF3*OEt2 / CH2Cl2 / 1 h / 0 °C
5: 83 percent / TsOH*H2O / pyridine; H2O / 12 h / 80 °C
6: 82 percent / TsOH*H2O / methanol / 4 h
7: 63 percent / (Bu3Sn)2O, 2M Br2 / CH2Cl2 / 1 h / 0 °C
8: 52 percent / TsOH*H2O / 10 h
9: 93 percent / pyridine / 12 h / Ambient temperature
10: 89 percent / Bu3SnH, AIBN / benzene / 1 h / Heating
With
pyridine; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; bromine; tri-n-butyl-tin hydride; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; bis(tri-n-butyltin)oxide;
In
pyridine; methanol; dichloromethane; water; acetonitrile; benzene;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 93 percent / NaBH4 / ethanol / 1 h / 55 °C
2: 88 percent / Et3N / acetonitrile / 1 h / -35 °C
3: 89 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 12.3 h / -10 °C
4: 77 percent / NaH, MgSO4 / CH2Cl2 / 10 h
5: 92 percent / 0.3M BF3*OEt2 / CH2Cl2 / 1 h / 0 °C
6: 83 percent / TsOH*H2O / pyridine; H2O / 12 h / 80 °C
7: 82 percent / TsOH*H2O / methanol / 4 h
8: 63 percent / (Bu3Sn)2O, 2M Br2 / CH2Cl2 / 1 h / 0 °C
9: 52 percent / TsOH*H2O / 10 h
10: 93 percent / pyridine / 12 h / Ambient temperature
11: 89 percent / Bu3SnH, AIBN / benzene / 1 h / Heating
With
pyridine; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; bromine; tri-n-butyl-tin hydride; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; bis(tri-n-butyltin)oxide;
In
pyridine; methanol; ethanol; dichloromethane; water; acetonitrile; benzene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 89 percent / 3-chloroperoxybenzoic acid / CH2Cl2 / 12.3 h / -10 °C
2: 77 percent / NaH, MgSO4 / CH2Cl2 / 10 h
3: 92 percent / 0.3M BF3*OEt2 / CH2Cl2 / 1 h / 0 °C
4: 83 percent / TsOH*H2O / pyridine; H2O / 12 h / 80 °C
5: 82 percent / TsOH*H2O / methanol / 4 h
6: 63 percent / (Bu3Sn)2O, 2M Br2 / CH2Cl2 / 1 h / 0 °C
7: 52 percent / TsOH*H2O / 10 h
8: 93 percent / pyridine / 12 h / Ambient temperature
9: 89 percent / Bu3SnH, AIBN / benzene / 1 h / Heating
With
pyridine; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; bromine; tri-n-butyl-tin hydride; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; bis(tri-n-butyltin)oxide;
In
pyridine; methanol; dichloromethane; water; benzene;
