methyl N-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}-N-ethylglycinate hydrochloride

Base Information

• Chemical Name: methyl N-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}-N-ethylglycinate hydrochloride
• CAS No.: 1376436-83-7
• Molecular Formula: C₃₆H₅₁N₃O₄*ClH
• Molecular Weight: 626.28
• Mol file: 1376436-83-7.mol

Synonyms:

Chemical Property of methyl N-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}-N-ethylglycinate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}-N-ethylglycinate hydrochloride

There total 7 articles about methyl N-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}-N-ethylglycinate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

methyl N-ethylglycinate hydrochloride (1121527-61-4) + 2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizine-7-carboxylic acid (1376436-87-1) → methyl N-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}-N-ethylglycinate hydrochloride (1376436-83-7)

Guidance literature:

Reference yield:

2-methyl-4-[(1-methylethoxy)carbonyl]-1-(2-oxohexyl)pyridinium bromide (1376436-76-8) → methyl N-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}-N-ethylglycinate hydrochloride (1376436-83-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium carbonate / isopropyl alcohol / 1.5 h / Reflux

2: 4.5 h / 85 °C

3: potassium carbonate; potassium iodide / acetonitrile / 72 h / Reflux

4: water; sodium hydroxide / 1,4-dioxane / 72 h / 5 - 25 °C

With water; sodium carbonate; potassium carbonate; potassium iodide; sodium hydroxide; In 1,4-dioxane; isopropyl alcohol; acetonitrile;

Reference yield:

1-methylethyl 2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizine-7-carboxylate (1376436-80-4) → methyl N-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}-N-ethylglycinate hydrochloride (1376436-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium hydroxide / 1,4-dioxane / 72 h / 5 - 25 °C

With water; sodium hydroxide; In 1,4-dioxane;

upstream raw materials:

1-methylethyl 2-methylpyridine-4-carboxylate

2-methyl-4-[(1-methylethoxy)carbonyl]-1-(2-oxohexyl)pyridinium bromide

1-methylethyl 2-butylindolizine-7-carboxylate

1-methylethyl 2-butyl-3-{[4-(3-chloropropyl)phenyl]carbonyl}indolizine-7-carboxylate