3-Hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione

Base Information

Chemical Name:3-Hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione
CAS No.:105922-93-8
Molecular Formula:C9H6ClNOS2
Molecular Weight:243.738
Hs Code.:
DSSTox Substance ID:DTXSID70430810
Nikkaji Number:J1.064.622G
Wikidata:Q82244525

Synonyms:N-hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione;NHCl-PTT

Suppliers and Price of 3-Hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:242.9579339
Heavy Atom Count:14
Complexity:274

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CSC(=S)N2O)Cl

Technology Process of 3-Hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione

There total 6 articles about 3-Hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136978-96-6
ω-bromo-p-chloroacetophenone oxime

: 105922-93-8
4-(p-chlorophenyl)-N-hydroxy-1,3-thiazole-2(3H)-thione

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / acetone / 4 h / 20 °C

2: 89 percent / ZnCl₂ / diethyl ether / 14 h / 20 °C

With zinc(II) chloride; In diethyl ether; acetone;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1275::AID-EJOC1275>3.0.CO;2-2

Reference yield:

: 536-38-9
4-chlorobenzoylmethyl bromide

: 105922-93-8
4-(p-chlorophenyl)-N-hydroxy-1,3-thiazole-2(3H)-thione

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / hydroxylamine hydrochloride / methanol

2: 97 percent / acetone

3: anhydr. ZnCl₂ / diethyl ether

With hydroxylamine hydrochloride; zinc(II) chloride; In methanol; diethyl ether; acetone;
DOI:10.1055/s-1997-5754

Reference yield:

: 99-91-2
para-chloroacetophenone

: 105922-93-8
4-(p-chlorophenyl)-N-hydroxy-1,3-thiazole-2(3H)-thione

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; hydrogen bromide; bromine / 2.25 h / 15 - 25 °C

2: hydroxylamine hydrochloride / ethanol; water / 24 h / 20 °C

3: acetone / 3.5 h / 20 °C

4: zinc(II) chloride / diethyl ether / 48 h / 0 - 20 °C

With hydroxylamine hydrochloride; hydrogen bromide; bromine; acetic acid; zinc(II) chloride; In diethyl ether; ethanol; water; acetone;
DOI:10.15227/orgsyn.079.0228