2-Piperazinecarboxylic acid, 4-(3-phosphono-2-propenyl)-, [S-(E)]-

Base Information

Chemical Name:2-Piperazinecarboxylic acid, 4-(3-phosphono-2-propenyl)-, [S-(E)]-
CAS No.:126330-85-6
Molecular Formula:C₈H₁₅N₂O₅P
Molecular Weight:250.191
Hs Code.:
DSSTox Substance ID:DTXSID001164954
Nikkaji Number:J445.447B,J655.025H

Synonyms:DTXSID001164954;126330-85-6;2-Piperazinecarboxylic acid, 4-(3-phosphono-2-propenyl)-, [S-(E)]-

Suppliers and Price of 2-Piperazinecarboxylic acid, 4-(3-phosphono-2-propenyl)-, [S-(E)]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Piperazinecarboxylic acid, 4-(3-phosphono-2-propenyl)-, [S-(E)]-

Chemical Property:

XLogP3:-7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:250.07185858
Heavy Atom Count:16
Complexity:326

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CC(N1)C(=O)O)CC=CP(=O)(O)O
Isomeric SMILES:C1CN(C[C@H](N1)C(=O)O)C/C=C/P(=O)(O)O

Technology Process of 2-Piperazinecarboxylic acid, 4-(3-phosphono-2-propenyl)-, [S-(E)]-

There total 3 articles about 2-Piperazinecarboxylic acid, 4-(3-phosphono-2-propenyl)-, [S-(E)]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 126330-84-5
(S)-4-[(E)-3-(Diethoxy-phosphoryl)-allyl]-piperazine-2-carboxylic acid

: 126330-85-6,137424-80-7
L-CPP-ene

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1002/hlca.19890720522

Reference yield:

: (S)-Piperazine-2-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: 126330-85-6,137424-80-7
L-CPP-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Et₃N / tetrahydrofuran / 20 h / -25 °C

2: BCl₃ / CH₂Cl₂; 1,2-dichloro-ethane / 1.) -25 deg C, 1h, 2.) 0 deg C, 3.5h

3: 55 percent / bromotrimethylsilane / CH₂Cl₂ / 16 h / Ambient temperature

With trimethylsilyl bromide; boron trichloride; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/hlca.19890720522

Reference yield:

: menthyl (S,E)-4-<3-(diethoxyphosphinyl)prop-2-enyl>piperazine-2-carboxylate

: 126330-85-6,137424-80-7
L-CPP-ene

Guidance literature:: Multi-step reaction with 2 steps

1: BCl₃ / CH₂Cl₂; 1,2-dichloro-ethane / 1.) -25 deg C, 1h, 2.) 0 deg C, 3.5h

2: 55 percent / bromotrimethylsilane / CH₂Cl₂ / 16 h / Ambient temperature

With trimethylsilyl bromide; boron trichloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/hlca.19890720522