(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(2,2,2-trifluoro-N-phenylacetamido)cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

Base Information

Chemical Name:(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(2,2,2-trifluoro-N-phenylacetamido)cyclopentyl 2-cyanoethyl diisopropylphosphoramidite
CAS No.:1379650-99-3
Molecular Formula:C₄₄H₅₁F₃N₃O₆P
Molecular Weight:805.874
Hs Code.:

(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(2,2,2-trifluoro-N-phenylacetamido)cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

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Chemical Property of (1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(2,2,2-trifluoro-N-phenylacetamido)cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

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Technology Process of (1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(2,2,2-trifluoro-N-phenylacetamido)cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

There total 5 articles about (1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(2,2,2-trifluoro-N-phenylacetamido)cyclopentyl 2-cyanoethyl diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1020110-10-4
(3S,4R)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentanone

: 1379650-99-3
(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(2,2,2-trifluoro-N-phenylacetamido)cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / tetrahydrofuran / 2 h / 20 °C

2.1: sodium cyanoborohydride / tetrahydrofuran / 16 h

3.1: triethylamine / dichloromethane / 2 h / 0 °C

4.1: boron trichloride / dichloromethane / 6 h / -78 °C

4.2: 16 h / -20 - 20 °C

5.1: pyridine / 4 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With pyridine; boron trichloride; sodium cyanoborohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0031-1289737

Reference yield:

: C₂₆H₂₇NO₂

: 1379650-99-3
(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(2,2,2-trifluoro-N-phenylacetamido)cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium cyanoborohydride / tetrahydrofuran / 16 h

2.1: triethylamine / dichloromethane / 2 h / 0 °C

3.1: boron trichloride / dichloromethane / 6 h / -78 °C

3.2: 16 h / -20 - 20 °C

4.1: pyridine / 4 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With pyridine; boron trichloride; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0031-1289737

Reference yield:

: N-{(3S,4R)-3-(benzyloxy)-4-[(benzyloxy)methyl]cyclopentyl}aniline

: 1379650-99-3
(1S,2R,4R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(2,2,2-trifluoro-N-phenylacetamido)cyclopentyl 2-cyanoethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 2 h / 0 °C

2.1: boron trichloride / dichloromethane / 6 h / -78 °C

2.2: 16 h / -20 - 20 °C

3.1: pyridine / 4 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With pyridine; boron trichloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0031-1289737