oxazol-5-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

Base Information

• Chemical Name: oxazol-5-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate
• CAS No.: 1383570-19-1
• Molecular Formula: C₃₇H₄₈N₆O₅S
• Molecular Weight: 688.891
• Mol file: 1383570-19-1.mol

Synonyms:

Chemical Property of oxazol-5-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of oxazol-5-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

There total 5 articles about oxazol-5-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate (1383570-59-9) → oxazol-5-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate (1383570-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 16 h

2: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 12 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/jm400288z

Reference yield:

tert-butyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate (1383570-15-7) → oxazol-5-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate (1383570-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 12 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/jm400288z

Reference yield:

(2R,5R)-1,6-diphenylhexane-2,5-diamine hydrochloride → oxazol-5-ylmethyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate (1383570-19-1)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / methanol / 16 h

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 16 h

3: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 12 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/jm400288z

upstream raw materials:

(S)-N-((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamide hydrochloride

carbonic acid 4-nitro-phenyl ester oxazol-5-ylmethyl ester

tert-butyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate

tert-butyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate