4-[3-(4-carbamoyl-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: 4-[3-(4-carbamoyl-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester
• CAS No.: 220271-11-4
• Molecular Formula: C₂₁H₂₂N₄O₇
• Molecular Weight: 442.428
• Mol file: 220271-11-4.mol

Synonyms:

Chemical Property of 4-[3-(4-carbamoyl-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(4-carbamoyl-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

There total 2 articles about 4-[3-(4-carbamoyl-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-<(4-carbamoylfuroxan-3-yl)methoxy>benzaldehyde (220270-89-3) → 4-[3-(4-carbamoyl-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester (220271-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃CO₂H / ethanol / 3 h / 0 °C

2: P(OCH₃)3 / 9 h / Heating

With trifluoroacetic acid; phosphorous acid trimethyl ester; In ethanol;

DOI:10.1021/jm9803267

Reference yield:

4-[3-(4-carbamoyl-2-oxy-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester → 4-[3-(4-carbamoyl-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester (220271-11-4)

Guidance literature:

With phosphorous acid trimethyl ester; for 9h; Heating;

DOI:10.1021/jm9803267

Reference yield:

4-[3-(4-carbamoyl-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester (220271-11-4) → 4-[3-(4-cyano-furazan-3-ylmethoxy)-phenyl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

Guidance literature:

With trifluoroacetic anhydride; In pyridine; for 0.5h; Ambient temperature;

DOI:10.1021/jm9803267

upstream raw materials:

4-<(4-carbamoylfuroxan-3-yl)methoxy>benzaldehyde