8-(4-methoxybenzyl)-4,5,6,8-tetrahydro-3-thia-1,7,8-triazacyclopenta[e]azulen-2-ylamine

Base Information

Chemical Name:8-(4-methoxybenzyl)-4,5,6,8-tetrahydro-3-thia-1,7,8-triazacyclopenta[e]azulen-2-ylamine
CAS No.:1314140-32-3
Molecular Formula:C₁₇H₁₈N₄OS
Molecular Weight:326.422
Hs Code.:

Synonyms:

Suppliers and Price of 8-(4-methoxybenzyl)-4,5,6,8-tetrahydro-3-thia-1,7,8-triazacyclopenta[e]azulen-2-ylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-(4-methoxybenzyl)-4,5,6,8-tetrahydro-3-thia-1,7,8-triazacyclopenta[e]azulen-2-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-(4-methoxybenzyl)-4,5,6,8-tetrahydro-3-thia-1,7,8-triazacyclopenta[e]azulen-2-ylamine

There total 12 articles about 8-(4-methoxybenzyl)-4,5,6,8-tetrahydro-3-thia-1,7,8-triazacyclopenta[e]azulen-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314139-89-3
5-bromo-2-(4-methoxybenzyl)-5,6,7,8-tetrahydro-2H-cycloheptapyrazol-4-one

: 17356-08-0
thiourea

: 1314140-32-3
8-(4-methoxybenzyl)-4,5,6,8-tetrahydro-3-thia-1,7,8-triazacyclopenta[e]azulen-2-ylamine

Guidance literature:: In ethanol; for 2h; Reflux;

Reference yield:

: 1355249-61-4
ethyl 3-bromo-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylate

: 1314140-32-3
8-(4-methoxybenzyl)-4,5,6,8-tetrahydro-3-thia-1,7,8-triazacyclopenta[e]azulen-2-ylamine

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / Reflux

2.1: sodium hydroxide / methanol / 2 h / Reflux

2.2: pH 2 - 3

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: magnesium / tetrahydrofuran / 60 - 70 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 18 h / Inert atmosphere; Reflux

7.1: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C / 760.05 Torr

8.1: phenyltrimethylammonium tribromide / chloroform / 0.5 h / Reflux

9.1: ethanol / 2 h / Reflux

With oxalyl dichloride; hydrogen; phenyltrimethylammonium tribromide; magnesium; triethylamine; sodium hydroxide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; toluene;

Reference yield:

: 1355249-63-6
C₁₄H₁₄N₂O₃

: 1314140-32-3
8-(4-methoxybenzyl)-4,5,6,8-tetrahydro-3-thia-1,7,8-triazacyclopenta[e]azulen-2-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: magnesium / tetrahydrofuran / 60 - 70 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 18 h / Inert atmosphere; Reflux

5.1: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C / 760.05 Torr

6.1: phenyltrimethylammonium tribromide / chloroform / 0.5 h / Reflux

7.1: ethanol / 2 h / Reflux

With oxalyl dichloride; hydrogen; phenyltrimethylammonium tribromide; magnesium; triethylamine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform;