Technology Process of (4,8,12,16-tetramethylheptadec-3-enyl) tosylate
There total 5 articles about (4,8,12,16-tetramethylheptadec-3-enyl) tosylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4,8,12,16-tetramethylheptadec-3-en-1-ol; p-toluenesulfonyl chloride;
With
trimethylamine hydrochloride; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
With
1-amino-3-(dimethylamino)propane;
In
dichloromethane;
at 0 ℃;
for 0.25h;
Product distribution / selectivity;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide / 10 h / 20 °C
1.2: 0 °C
2.1: potassium hydroxide; water / ethanol / 18 h / 80 °C
3.1: sulfuric acid / 12 h / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 50 °C / Inert atmosphere
4.2: Cooling with ice; Inert atmosphere
5.1: triethylamine; trimethylamine hydrochloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
5.2: 0.25 h / 0 °C / Inert atmosphere
With
lithium aluminium tetrahydride; sulfuric acid; water; trimethylamine hydrochloride; triethylamine; potassium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / 12 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 50 °C / Inert atmosphere
2.2: Cooling with ice; Inert atmosphere
3.1: triethylamine; trimethylamine hydrochloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.2: 0.25 h / 0 °C / Inert atmosphere
With
lithium aluminium tetrahydride; sulfuric acid; trimethylamine hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane;
