N-Benzyl-N-[(R)-thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-hydroxylamine

Base Information

• Chemical Name: N-Benzyl-N-[(R)-thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-hydroxylamine
• CAS No.: 191997-85-0
• Molecular Formula: C₄₅H₄₆N₂O₆S
• Molecular Weight: 742.936
• Mol file: 191997-85-0.mol

Synonyms:

Chemical Property of N-Benzyl-N-[(R)-thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyl-N-[(R)-thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-hydroxylamine

There total 1 articles about N-Benzyl-N-[(R)-thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-lithiothiazole (40610-14-8) + C42H43NO6 (191997-57-6) → N-Benzyl-N-[(S)-thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-hydroxylamine (191997-61-2) + N-Benzyl-N-[(R)-thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-hydroxylamine (191997-85-0)

Guidance literature:

In tetrahydrofuran; at -80 ℃; for 0.25h; Product distribution; effect of the presence of Et₂AlCl; other solvent, reaction time;

DOI:10.1021/jo970290a

Reference yield:

N-Benzyl-N-[(R)-thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-hydroxylamine (191997-85-0) → C-[(R)-C-Thiazol-2-yl-C-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)]-methylamine

Guidance literature:

With titanium(III) chloride; In methanol; water; for 0.25h; Ambient temperature;

DOI:10.1021/jo970290a

Reference yield:

N-Benzyl-N-[(R)-thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-hydroxylamine (191997-85-0) → [(R)-2-Oxo-1-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: TiCl₃ / methanol; H₂O / 0.25 h / Ambient temperature

2: dioxane / 12 h / Ambient temperature

With titanium(III) chloride; In 1,4-dioxane; methanol; water;

DOI:10.1021/jo970290a

upstream raw materials:

2-lithiothiazole

C₄₂H₄₃NO₆

Downstream raw materials:

[(R)-Thiazol-2-yl-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-methyl]-carbamic acid tert-butyl ester