Sitagliptin EP Impurity C

Base Information

• Chemical Name: Sitagliptin EP Impurity C
• CAS No.: 1345822-86-7
• Molecular Formula: C₁₆H₁₆F₅N₅O*H₃O₄P
• Molecular Weight: 487.323
• Mol file: 1345822-86-7.mol

Synonyms:

Chemical Property of Sitagliptin EP Impurity C

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

5-DesfluoroSitagliptinPhosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Desfluoro Sitagliptin is a metabolite of Sitagliptin phosphate (S491000). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.

Technology Process of Sitagliptin EP Impurity C

There total 1 articles about Sitagliptin EP Impurity C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3(R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(3,4-difluorophenyl)butan-1-one phosphate (1345822-86-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; benzyl chloride; In ethanol; water; at 40 ℃; under 2068.65 Torr; Autoclave; Inert atmosphere;

With phosphoric acid; In ethanol; water; at 75 ℃;

Refernces