Technology Process of tert-butyl 6-bromo-5-(cyclohexyloxy)-3-(3-sulfamoylphenyl)-1H-indazole-1-carboxylate
There total 7 articles about tert-butyl 6-bromo-5-(cyclohexyloxy)-3-(3-sulfamoylphenyl)-1H-indazole-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate;
In
tetrahydrofuran;
for 6h;
Inert atmosphere;
Reflux;
DOI:10.1021/jm4000215
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium hydroxide / acetonitrile / 22 h / 0 - 20 °C
2: sodium dithionite; ethanol / water / 5 h / 100 °C
3: acetic acid; sodium nitrite / water / 20 °C
4: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C
5: triethylamine / acetonitrile / 0.83 h / 20 °C
6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / tetrahydrofuran / 6 h / Inert atmosphere; Reflux
With
sodium dithionite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; ethanol; iodine; sodium carbonate; acetic acid; triethylamine; potassium hydroxide; sodium nitrite;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
1: |Suzuki Coupling / 6: |Suzuki Coupling;
DOI:10.1021/jm4000215
- Guidance literature:
-
Multi-step reaction with 3 steps
1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C
2: triethylamine / acetonitrile / 0.83 h / 20 °C
3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / tetrahydrofuran / 6 h / Inert atmosphere; Reflux
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; iodine; sodium carbonate; triethylamine; potassium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
3: |Suzuki Coupling;
DOI:10.1021/jm4000215