Technology Process of (6-{(benzenesulfonyl)[4-(1,1-dimethylpentyl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid
There total 8 articles about (6-{(benzenesulfonyl)[4-(1,1-dimethylpentyl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice
1.2: 1.17 h / 20 °C / Cooling with ice
2.1: calcium chloride; potassium borohydride / Tetraethylene glycol dimethyl ether; ethanol / 0.92 h / 20 - 35 °C / Cooling with ice
2.2: 1.17 h / 20 °C / Cooling with ice
3.1: Dess-Martin periodane / dichloromethane / 2.33 h / Cooling with ice; Inert atmosphere
4.1: hydroxylamine hydrochloride; pyridine / methanol / 1 h / 20 °C
5.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 20 °C / 760.05 Torr
6.1: dichloromethane / 18 h / 20 °C
6.2: 18 h / 20 °C
7.1: triethylamine / dichloromethane / 12 h / 20 °C
8.1: trifluoroacetic acid / dichloromethane / 36 h / 20 °C
8.2: pH 4.2
With
pyridine; potassium borohydride; hydroxylamine hydrochloride; hydrogen; sodium hydride; Dess-Martin periodane; triethylamine; trifluoroacetic acid; calcium chloride;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; Tetraethylene glycol dimethyl ether; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: Dess-Martin periodane / dichloromethane / 2.33 h / Cooling with ice; Inert atmosphere
2.1: hydroxylamine hydrochloride; pyridine / methanol / 1 h / 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 20 °C / 760.05 Torr
4.1: dichloromethane / 18 h / 20 °C
4.2: 18 h / 20 °C
5.1: triethylamine / dichloromethane / 12 h / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 36 h / 20 °C
6.2: pH 4.2
With
pyridine; hydroxylamine hydrochloride; hydrogen; Dess-Martin periodane; triethylamine; trifluoroacetic acid;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydroxylamine hydrochloride; pyridine / methanol / 1 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 20 °C / 760.05 Torr
3.1: dichloromethane / 18 h / 20 °C
3.2: 18 h / 20 °C
4.1: triethylamine / dichloromethane / 12 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 36 h / 20 °C
5.2: pH 4.2
With
pyridine; hydroxylamine hydrochloride; hydrogen; triethylamine; trifluoroacetic acid;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; water;