methyl 6-deoxy-6-(3-chloro-4-(5-trifluoromethyl-2(1H)-pyridone-1-yl)-anilino)-α-D-mannopyranoside

Base Information

• Chemical Name: methyl 6-deoxy-6-(3-chloro-4-(5-trifluoromethyl-2(1H)-pyridone-1-yl)-anilino)-α-D-mannopyranoside
• CAS No.: 1372204-43-7
• Molecular Formula: C₁₉H₂₀ClF₃N₂O₆
• Molecular Weight: 464.826
• Mol file: 1372204-43-7.mol

Synonyms:

Chemical Property of methyl 6-deoxy-6-(3-chloro-4-(5-trifluoromethyl-2(1H)-pyridone-1-yl)-anilino)-α-D-mannopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-deoxy-6-(3-chloro-4-(5-trifluoromethyl-2(1H)-pyridone-1-yl)-anilino)-α-D-mannopyranoside

There total 7 articles about methyl 6-deoxy-6-(3-chloro-4-(5-trifluoromethyl-2(1H)-pyridone-1-yl)-anilino)-α-D-mannopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H26ClF3N2O9 → methyl 6-deoxy-6-(3-chloro-4-(5-trifluoromethyl-2(1H)-pyridone-1-yl)-anilino)-α-D-mannopyranoside (1372204-43-7)

Guidance literature:

C₂₅H₂₆ClF₃N₂O₉; With sodium methylate; In methanol; at 20 ℃; for 0.5h;

In methanol;

DOI:10.3390/molecules17010884

Reference yield:

(2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol (617-04-9) → methyl 6-deoxy-6-(3-chloro-4-(5-trifluoromethyl-2(1H)-pyridone-1-yl)-anilino)-α-D-mannopyranoside (1372204-43-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: pyridine; dmap / 5 h / 60 °C

2.1: 2 h / 20 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / 20 °C

4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 20 °C

5.1: methanol / 0.17 h / 20 °C / Inert atmosphere

6.1: sodium cyanoborohydride / methanol / 0.5 h / 20 °C

6.2: Saturated solution

7.1: sodium methylate / methanol / 0.5 h / 20 °C

7.2: Amberlite IR 120-H⁺

With pyridine; dmap; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; boron trifluoride diethyl etherate; sodium methylate; sodium cyanoborohydride; In methanol; dichloromethane;

DOI:10.3390/molecules17010884

Reference yield:

C2H4O2*C25H24ClF3N2O9 → methyl 6-deoxy-6-(3-chloro-4-(5-trifluoromethyl-2(1H)-pyridone-1-yl)-anilino)-α-D-mannopyranoside (1372204-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium cyanoborohydride / methanol / 0.5 h / 20 °C

1.2: Saturated solution

2.1: sodium methylate / methanol / 0.5 h / 20 °C

2.2: Amberlite IR 120-H⁺

With sodium methylate; sodium cyanoborohydride; In methanol;

DOI:10.3390/molecules17010884

upstream raw materials:

(2S,3S,4S,5R,6R)-2-methoxy-6-((trityloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

(2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol

methyl 2,3,4-tri-O-acetyl-6-aldehydo-α-D-manno-hexodialdo-1,5-pyranoside

methyl 2,3,4-tri-O-acetyl-α-D-mannopyranoside