Technology Process of C20H17ClFN3O2S
There total 9 articles about C20H17ClFN3O2S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; potassium hydroxide;
In
acetonitrile;
at 85 ℃;
for 0.75h;
DOI:10.1021/ml4000996
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ethylmagnesium bromide / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C
1.2: 1 h / 20 °C
1.3: 4 h / Reflux
2.1: hydrogenchloride / methanol / 2 h / Reflux
3.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C
4.1: N-iodo-succinimide; trifluoroacetic acid / dichloromethane / 3 h / 20 °C
5.1: potassium carbonate; copper(l) iodide / isopropyl alcohol / 16 h / 80 °C / Inert atmosphere
6.1: potassium hydroxide; water / acetonitrile / 0.75 h / 85 °C
With
hydrogenchloride; N-iodo-succinimide; copper(l) iodide; ethylmagnesium bromide; water; potassium carbonate; caesium carbonate; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/ml4000996
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; copper(l) iodide / isopropyl alcohol / 16 h / 80 °C / Inert atmosphere
2: potassium hydroxide; water / acetonitrile / 0.75 h / 85 °C
With
copper(l) iodide; water; potassium carbonate; potassium hydroxide;
In
isopropyl alcohol; acetonitrile;
DOI:10.1021/ml4000996
