C₂₇H₂₈N₆O₂

Base Information

• Chemical Name: C₂₇H₂₈N₆O₂
• CAS No.: 1547160-62-2
• Molecular Formula: C₂₇H₂₈N₆O₂
• Molecular Weight: 468.558
• Mol file: 1547160-62-2.mol

Synonyms:

Chemical Property of C₂₇H₂₈N₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₈N₆O₂

There total 7 articles about C₂₇H₂₈N₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H9N3O5 (1547160-84-8) → C27H28N6O2 (1547160-62-2)

Guidance literature:

Multi-step reaction with 6 steps

1: trichlorophosphate; thionyl chloride / 3 h / 90 °C

2: isopropyl alcohol / 2 h / 50 °C

3: ammonium chloride; iron / N,N-dimethyl-formamide; water / 1 h / 80 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 110 °C

5: triethylamine / dichloromethane / 24 h / 35 °C

6: N,N-dimethyl-formamide / 1 h / 20 °C

With thionyl chloride; iron; potassium carbonate; ammonium chloride; triethylamine; potassium iodide; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.12.079

Reference yield:

7-fluoro-6-nitro-3H-quinazolin-4-one (162012-69-3) → C27H28N6O2 (1547160-62-2)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium hydride / tetrahydrofuran / 20 h / 75 °C

2: trichlorophosphate; thionyl chloride / 3 h / 90 °C

3: isopropyl alcohol / 2 h / 50 °C

4: ammonium chloride; iron / N,N-dimethyl-formamide; water / 1 h / 80 °C

5: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 110 °C

6: triethylamine / dichloromethane / 24 h / 35 °C

7: N,N-dimethyl-formamide / 1 h / 20 °C

With thionyl chloride; iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; potassium iodide; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.12.079

Reference yield:

C10H7Cl2N3O3 (1547160-88-2) → C27H28N6O2 (1547160-62-2)

Guidance literature:

Multi-step reaction with 5 steps

1: isopropyl alcohol / 2 h / 50 °C

2: ammonium chloride; iron / N,N-dimethyl-formamide; water / 1 h / 80 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 110 °C

4: triethylamine / dichloromethane / 24 h / 35 °C

5: N,N-dimethyl-formamide / 1 h / 20 °C

With iron; potassium carbonate; ammonium chloride; triethylamine; potassium iodide; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.12.079

upstream raw materials:

7-fluoro-6-nitro-3H-quinazolin-4-one

C₁₀H₉N₃O₅

C₁₀H₇Cl₂N₃O₃

C₁₈H₁₃ClN₄O₃