1-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidoprop-yl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one 3-(2-cyanoethyl-diisopropylphosphoramidite)

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Chemical Name:1-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidoprop-yl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one 3-(2-cyanoethyl-diisopropylphosphoramidite)
CAS No.:1403243-72-0
Molecular Formula:C₄₉H₆₀F₃N₈O₉P
Molecular Weight:993.033
Hs Code.:

1-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidoprop-yl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one 3-(2-cyanoethyl-diisopropylphosphoramidite)

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Chemical Property of 1-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidoprop-yl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one 3-(2-cyanoethyl-diisopropylphosphoramidite)

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Technology Process of 1-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidoprop-yl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one 3-(2-cyanoethyl-diisopropylphosphoramidite)

There total 4 articles about 1-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidoprop-yl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one 3-(2-cyanoethyl-diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403243-79-7
1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidopropynyl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one

: 1403243-72-0
1-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidoprop-yl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one 3-(2-cyanoethyl-diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 3800.26 Torr

2: pyridine / 20 °C

3: diisopropylethylamine tetrazolium / dichloromethane / 2 h / 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.05.044

Reference yield:

: 14719-21-2
trifluoroacetyl-propargyl amine

: 1403243-72-0
1-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidoprop-yl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one 3-(2-cyanoethyl-diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 4 h / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 3800.26 Torr

3.1: pyridine / 20 °C

4.1: diisopropylethylamine tetrazolium / dichloromethane / 2 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.05.044

Reference yield:

: 215178-27-1
1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,5-dihydro-3-iodo-6-[(2-methylpropanoyl)amino]-4H-pyrazolo[3,4-d]pyrimidin-4-one

: 1403243-72-0
1-[2-deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl]-1,5-dihydro-6-[(2-methylpropanoyl)amino]-3-(3-trifluoroacetamidoprop-yl)-4H-pyrazolo[3,4-d]-pyrimidin-4-one 3-(2-cyanoethyl-diisopropylphosphoramidite)

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 4 h / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 3800.26 Torr

3.1: pyridine / 20 °C

4.1: diisopropylethylamine tetrazolium / dichloromethane / 2 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.05.044