Technology Process of (1R,4S)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-methyl-cyclohexanol
There total 11 articles about (1R,4S)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-methyl-cyclohexanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) ozone, 2.) Me2S / 1.) methanol, -78 deg C, 2.) methanol, RT, 8 h
2: ethylmagnesium bromide / tetrahydrofuran / 2 h / Ambient temperature
3: KOH / dimethylsulfoxide / 0.25 h / Ambient temperature
4: 1.) n-BuLi / 1.) THF, hexane, RT, 5 min, 2.) THF, hexane, RT, 1 h
5: 40percent HF / acetonitrile / 0.5 h
6: 100 percent / LiAlH4 / diethyl ether / 1 h / 0 °C
7: LiAlH4, TiCl3 / diethyl ether; tetrahydrofuran / 1 h / Heating
With
potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; titanium(III) chloride; dimethylsulfide; hydrogen fluoride; ethylmagnesium bromide; ozone;
In
tetrahydrofuran; diethyl ether; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jo00392a012
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ethylmagnesium bromide / tetrahydrofuran / 2 h / Ambient temperature
2: KOH / dimethylsulfoxide / 0.25 h / Ambient temperature
3: 1.) n-BuLi / 1.) THF, hexane, RT, 5 min, 2.) THF, hexane, RT, 1 h
4: 40percent HF / acetonitrile / 0.5 h
5: 100 percent / LiAlH4 / diethyl ether / 1 h / 0 °C
6: LiAlH4, TiCl3 / diethyl ether; tetrahydrofuran / 1 h / Heating
With
potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; titanium(III) chloride; hydrogen fluoride; ethylmagnesium bromide;
In
tetrahydrofuran; diethyl ether; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jo00392a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: KOH / dimethylsulfoxide / 0.25 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, RT, 5 min, 2.) THF, hexane, RT, 1 h
3: 40percent HF / acetonitrile / 0.5 h
4: 100 percent / LiAlH4 / diethyl ether / 1 h / 0 °C
5: LiAlH4, TiCl3 / diethyl ether; tetrahydrofuran / 1 h / Heating
With
potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; titanium(III) chloride; hydrogen fluoride;
In
tetrahydrofuran; diethyl ether; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jo00392a012
