4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-α-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide

Base Information

• Chemical Name: 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-α-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide
• CAS No.: 129986-34-1
• Molecular Formula: C₄₁H₇₃NO₁₀Si₂
• Molecular Weight: 796.202

Synonyms:

Chemical Property of 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-α-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-α-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide

There total 32 articles about 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-α-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranose acetate (129986-33-0) + (R)-3-((4R,5S,6S)-2,2-Di-tert-butyl-6-isopropenyl-5-methyl-[1,3,2]dioxasilinan-4-yl)-N-methoxy-2-(4-methoxy-benzyloxy)-N-methyl-3-oxo-propionamide → 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide (129986-34-1,129986-35-2,129986-48-7,129986-49-8) + 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-α-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide (129986-34-1,129986-35-2,129986-48-7,129986-49-8)

Guidance literature:

With triphenylmethyl perchlorate; In toluene; at -8 - -5 ℃; for 1.41667h;

DOI:10.1021/ja00175a038

Reference yield: 70.0%

2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranose acetate (129986-33-0) + (R)-3-((4R,5S,6S)-2,2-Di-tert-butyl-6-isopropenyl-5-methyl-[1,3,2]dioxasilinan-4-yl)-N-methoxy-2-(4-methoxy-benzyloxy)-N-methyl-3-oxo-propionamide → 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide (129986-34-1,129986-35-2,129986-48-7,129986-49-8) + 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-α-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide (129986-34-1,129986-35-2,129986-48-7,129986-49-8)

Guidance literature:

With triphenylmethyl perchlorate; In toluene; at -8 - -5 ℃; for 1.41667h;

DOI:10.1021/ja00175a038

Reference yield: 70.0%

2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranose acetate (129986-33-0) + <2S,3S,4R,5S,6S>-2-<(4-methoxyphenyl)methoxy>-3,4,6-trihydroxy-N,5-dimethyl-4,6-O--7-methylene-N-methoxyoctanamide (129986-24-9,130011-57-3) → 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide (129986-34-1,129986-35-2,129986-48-7,129986-49-8) + 4,6-O--5,7,8-trideoxy-3-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-α-D-ribo-hexopyranosyl>-N-methoxy-2-O-<(4-methoxyphenyl)methyl>-N,5,7-trimethyl-D-glycero-L-ido-oct-7-enonamide (129986-34-1,129986-35-2,129986-48-7,129986-49-8)

Guidance literature:

With triphenylmethyl perchlorate; In toluene; at -8 - -5 ℃; for 1.41667h;

DOI:10.1021/ja00175a038

upstream raw materials:

2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranose acetate

<2S,3S,4R,5S,6S>-2-<(4-methoxyphenyl)methoxy>-3,4,6-trihydroxy-N,5-dimethyl-4,6-O--7-methylene-N-methoxyoctanamide

p-methoxybenzyloxy acetic acid

<2R,3S,4S>-2,4-O--3-methyl-5-methylene-1,2,4-hexanetriol

Downstream raw materials:

5,7-O--1,6,8,9-tetradeoxy-4-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranosyl>-3-O-<(4-methoxyphenyl)methyl>-6,8-dimethyl-D-glycero-L-ido-non-8-en-2-ulose

<4R-<4α(1R^*,2R^*,3R^*),5α,6α>>-<1-<2,2-bis(1,1-dimethylethyl)-5-methyl-6-(1-methylethenyl)-1,3-dioxa-2-silacycyclohex-4-yl>-2,3-dihydroxy-3-methyl-7-(phenylthio)heptyl> 2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranoside

<4R-<4α(1R^*,2R^*,3R^*),5α,6α>>-<1-<2,2-bis(1,1-dimethylethyl)-5-methyl-6-(1-methylethenyl)-1,3-dioxa-2-silacycyclohex-4-yl>-2,3-bis<(triethylsilyl)oxy>-3-methyl-7-(phenylthio)heptyl> 2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyr...

3,5-O--4,9,10,11,12-pentadeoxy-6-O-<2,6-dideoxy-3-O-methyl-4-O-(triethylsilyl)-β-D-ribo-hexopyranosyl>-4-methyl-2,8-di-C-methyl-12-(phenylsulfonyl)-7,8-bis-O-(triethylsilyl)-D-xylo-L-gulo-dodecitol

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