2-(2-chlorophenyl)-2-nitrocyclohexan-1-one

Base Information

• Chemical Name: 2-(2-chlorophenyl)-2-nitrocyclohexan-1-one
• CAS No.: 2079878-75-2
• Molecular Formula: C₁₂H₁₂ClNO₃
• Molecular Weight: 253.685

Synonyms:

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Chemical Property of 2-(2-chlorophenyl)-2-nitrocyclohexan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-chlorophenyl)-2-nitrocyclohexan-1-one

There total 6 articles about 2-(2-chlorophenyl)-2-nitrocyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-amino-2-(2-chlorophenyl)cyclohexan-1-one (91393-49-6) → 2-(2-chlorophenyl)-2-nitrocyclohexan-1-one (2079878-75-2)

Guidance literature:

With ammonium cerium (IV) nitrate; copper diacetate; In 1,2-dichloro-ethane; at 80 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.7b00040

Reference yield: 41.0%

2-nitrocyclohexanone (4883-67-4) + trifluoromethanesulfonic acid di(o-chlorophenyl)iodonium salt → 2-(2-chlorophenyl)-2-nitrocyclohexan-1-one (2079878-75-2)

Guidance literature:

2-nitrocyclohexanone; With potassium carbonate; In 1,2-dichloro-ethane; at 20 ℃; for 0.166667h; Inert atmosphere;

trifluoromethanesulfonic acid di(o-chlorophenyl)iodonium salt; In 1,2-dichloro-ethane; at 80 ℃; Inert atmosphere;

DOI:10.1039/c8cc08920e

Reference yield:

2-bromo-1-chlorobenzene (694-80-4) → 2-(2-chlorophenyl)-2-nitrocyclohexan-1-one (2079878-75-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 5 h / -90 °C

1.2: 0 °C

2.1: Dess-Martin periodane / dichloromethane

3.1: ammonium cerium (IV) nitrate; copper diacetate / 1,2-dichloro-ethane / 12 h / 100 °C / Inert atmosphere; Sealed tube

With ammonium cerium (IV) nitrate; tert.-butyl lithium; copper diacetate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

upstream raw materials:

2-amino-2-(2-chlorophenyl)cyclohexan-1-one

2-bromo-1-chlorobenzene

cyclohexane-1,2-epoxide

2-nitrocyclohexanone

Downstream raw materials:

norketamine

ketamine