Technology Process of 2-cyano-3-<2-(4-bromophenyl)ethyl>pyridine
There total 6 articles about 2-cyano-3-<2-(4-bromophenyl)ethyl>pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 130.5 g / sodium methoxide / toluene / Heating; overnight
2: 9.1 g / 48percent aq. HBr / 24 h / Heating
3: 87.2 g / NaOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 1) reflux, 1 h, 2) 200 deg C, 3 h
4: 8.6 g / m-chloroperoxybenzoic acid / CH2Cl2 / 2 h / 25 °C
5: 1) dimethyl sulfate / 1) 100 deg C, 3 h, 2) water, overnight
With
sodium hydroxide; hydrogen bromide; sodium methylate; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; dimethyl sulfate;
In
dichloromethane; toluene; diethylene glycol;
DOI:10.1002/jhet.5570230154
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 130.5 g / sodium methoxide / toluene / Heating; overnight
2: 9.1 g / 48percent aq. HBr / 24 h / Heating
3: 87.2 g / NaOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 1) reflux, 1 h, 2) 200 deg C, 3 h
4: 8.6 g / m-chloroperoxybenzoic acid / CH2Cl2 / 2 h / 25 °C
5: 1) dimethyl sulfate / 1) 100 deg C, 3 h, 2) water, overnight
With
sodium hydroxide; hydrogen bromide; sodium methylate; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; dimethyl sulfate;
In
dichloromethane; toluene; diethylene glycol;
DOI:10.1002/jhet.5570230154
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 8.6 g / m-chloroperoxybenzoic acid / CH2Cl2 / 2 h / 25 °C
2: 1) dimethyl sulfate / 1) 100 deg C, 3 h, 2) water, overnight
With
3-chloro-benzenecarboperoxoic acid; dimethyl sulfate;
In
dichloromethane;
DOI:10.1002/jhet.5570230154
