O^ω-<(5S,R)-5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5-(2,2-dimethylpropyl)pentanoyl>-N^α-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester

Base Information

• Chemical Name: O^ω-<(5S,R)-5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5-(2,2-dimethylpropyl)pentanoyl>-N^α-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester
• CAS No.: 143508-34-3
• Molecular Formula: C₄₃H₆₈N₂O₁₁
• Molecular Weight: 789.02

Synonyms:

Chemical Property of O^ω-<(5S,R)-5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5-(2,2-dimethylpropyl)pentanoyl>-N^α-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O^ω-<(5S,R)-5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5-(2,2-dimethylpropyl)pentanoyl>-N^α-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester

There total 1 articles about O^ω-<(5S,R)-5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5-(2,2-dimethylpropyl)pentanoyl>-N^α-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-benzyloxycarbonylamino-3-hydroxy-propionic acid tert-butyl ester (59859-77-7) + (1S,R)-1-(2,2-dimethylpropyl)-5-oxo-5-hydroxypentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate (143508-62-7,143508-63-8) → Oω-<(5S,R)-5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5-(2,2-dimethylpropyl)pentanoyl>-Nα-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester (143508-34-3,143614-73-7)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 ℃;

DOI:10.1021/jm00099a004

Reference yield:

Oω-<(5S,R)-5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5-(2,2-dimethylpropyl)pentanoyl>-Nα-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester (143508-34-3,143614-73-7) → (3R,4S,7S)-7-Amino-4-cyclohexylmethyl-14-(2,2-dimethyl-propyl)-3-hydroxy-1,9-dioxa-5-aza-cyclotetradecane-2,6,10-trione

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

2: N-methylmorpholine, hydroxybenzotriazole (HOBt), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / tetrahydrofuran / 144 h / Ambient temperature

3: H₂ / 10 percent Pd/C / methanol / 760 Torr

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm00099a004

Reference yield:

Oω-<(5S,R)-5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5-(2,2-dimethylpropyl)pentanoyl>-Nα-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester (143508-34-3,143614-73-7) → (9S,12S,13R)-12-(cyclohexylmethyl)-9--L-phenylalanyl>-2-(2,2-dimethylpropyl)-13-hydroxy-6,10,14-trioxo-1,7-dioxa-11-azacyclotetradecane (137226-83-6,143614-55-5,143614-56-6)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid (TFA) / CH₂Cl₂ / Ambient temperature

2: N-methylmorpholine, hydroxybenzotriazole (HOBt), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / tetrahydrofuran / 144 h / Ambient temperature

3: H₂ / 10 percent Pd/C / methanol / 760 Torr

4: hydroxybenzotriazole monohydrate (HOBt), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm00099a004

upstream raw materials:

2-benzyloxycarbonylamino-3-hydroxy-propionic acid tert-butyl ester

(1S,R)-1-(2,2-dimethylpropyl)-5-oxo-5-hydroxypentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

Downstream raw materials:

(9S,12S,13R)-12-(cyclohexylmethyl)-2-(2,2-dimethylpropyl)-13-hydroxy-9-<<(phenylmethoxy)carbonyl>amino>-6,10,14-trioxo-1,5-dioxa-11-azacyclotetradecane

(9S,12S,13R)-12-(cyclohexylmethyl)-9--L-phenylalanyl>-2-(2,2-dimethylpropyl)-13-hydroxy-6,10,14-trioxo-1,7-dioxa-11-azacyclotetradecane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 143508-34-3 O^ω-<(5S,R)-5-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-5-(2,2-dimethylpropyl)pentanoyl>-N^α-<(phenylmethoxy)carbonyl>-L-serine, 1,1-dimethylethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send