N-isonicotinoyl-N'-thiobenzoylhydrazine

Base Information

• Chemical Name: N-isonicotinoyl-N'-thiobenzoylhydrazine
• CAS No.: 440106-97-8
• Molecular Formula: C₁₃H₁₁N₃OS
• Molecular Weight: 257.316
• Mol file: 440106-97-8.mol

Synonyms:

Chemical Property of N-isonicotinoyl-N'-thiobenzoylhydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-isonicotinoyl-N'-thiobenzoylhydrazine

There total 1 articles about N-isonicotinoyl-N'-thiobenzoylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoniazid (54-85-3,7640-37-1) + Carboxymethyl dithiobenzoate (942-91-6) → N-isonicotinoyl-N'-thiobenzoylhydrazine (440106-97-8)

Guidance literature:

With sodium hydroxide;

Reference yield: 60.0%

N-isonicotinoyl-N'-thiobenzoylhydrazine (440106-97-8) + nickel(II) acetate tetrahydrate (6018-89-9) → (N-isonicotinoyl-N'-thiobenzoylhydrazine)2(CH3COO)2Ni(II) (440107-04-0)

Guidance literature:

With CH₃COONa; In methanol; water; byproducts: H2O; soln. of C6H5CSNHNHCO(C5H4N) in CH3OH added to Ni acetate in CH3OH/H2O (50 vol-%) in the presence of Na acetate, digested for 0.5 h on boiling water bath; ppt. filtered off, washed with CH3OH/H2O, water, and ethanol, dried in vac.; elem. anal.;

DOI:10.1081/SIM-120003203

Reference yield: 55.0%

nickel(II) chloride hexahydrate + N-isonicotinoyl-N'-thiobenzoylhydrazine (440106-97-8) → (N-isonicotinoyl-N'-thiobenzoylhydrazine)2 nickel(II) dichloride (440106-99-0)

Guidance literature:

With HCl; In methanol; byproducts: H2O; soln. of C6H5CSNHNHCO(C5H4N) and Ni(H2O)6Cl2 in CH3OH heated at reflux in the presence of HCl (5-6 drops) for 15 min on water bath; ppt. filtered off, washed with CH3OH, dried in vac.; elem. anal.;

DOI:10.1081/SIM-120003203

upstream raw materials:

isoniazid

Carboxymethyl dithiobenzoate

Downstream raw materials:

(N-isonicotinoyl-N'-thiobenzoylhydrazine)2 nickel(II) dichloride

(N-isonicotinoyl-N'-thiobenzoylhydrazine)2(CH₃COO)2Ni(II)

(N-isonicotinoyl-N'-thiobenzoylhydrazine)2 cobalt(II) dichloride

(N-isonicotinoyl-N'-thiobenzoylhydrazine)2 zinc(II) dichloride