bromo-1 t-butyldimethylsilyloxymethyl-6 methyl-3 cyclohexene trans

Base Information

• Chemical Name: bromo-1 t-butyldimethylsilyloxymethyl-6 methyl-3 cyclohexene trans
• CAS No.: 79802-26-9
• Molecular Formula: C₁₄H₂₇BrOSi
• Molecular Weight: 319.357
• Mol file: 79802-26-9.mol

Synonyms:

Chemical Property of bromo-1 t-butyldimethylsilyloxymethyl-6 methyl-3 cyclohexene trans

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bromo-1 t-butyldimethylsilyloxymethyl-6 methyl-3 cyclohexene trans

There total 5 articles about bromo-1 t-butyldimethylsilyloxymethyl-6 methyl-3 cyclohexene trans which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydroxymethylene-2 methyl-5 cyclohexanone (142235-64-1) → bromo-1 t-butyldimethylsilyloxymethyl-6 methyl-3 cyclohexene trans (79802-26-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / NaH, AlH₃ / tetrahydrofuran

2: imidazole / dimethylformamide

3: 87 percent / methanol

4: 1) sec-BuLi 3) 1,2-dibromoethane / 1) DME, -80 deg C, 2 h, 2) DME,-40 deg C, 3 min, 3) DME, -40 deg C to room temp., 30 min

With 1H-imidazole; aluminium hydride; sec.-butyllithium; sodium hydride; ethylene dibromide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)91579-0

Reference yield:

hydroxymethyl-2 methyl-5 cyclohexanone (57654-89-4,89293-71-0) → bromo-1 t-butyldimethylsilyloxymethyl-6 methyl-3 cyclohexene trans (79802-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole / dimethylformamide

2: 87 percent / methanol

3: 1) sec-BuLi 3) 1,2-dibromoethane / 1) DME, -80 deg C, 2 h, 2) DME,-40 deg C, 3 min, 3) DME, -40 deg C to room temp., 30 min

With 1H-imidazole; sec.-butyllithium; ethylene dibromide; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)91579-0

Reference yield:

t-butyldimethylsilyloxymethyl-2 methyl-5 cyclohexanone trans (89293-72-1,89293-80-1) → bromo-1 t-butyldimethylsilyloxymethyl-6 methyl-3 cyclohexene trans (79802-26-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / methanol

2: 1) sec-BuLi 3) 1,2-dibromoethane / 1) DME, -80 deg C, 2 h, 2) DME,-40 deg C, 3 min, 3) DME, -40 deg C to room temp., 30 min

With sec.-butyllithium; ethylene dibromide; In methanol;

DOI:10.1016/S0040-4020(01)91579-0

upstream raw materials:

hydroxymethyl-2 methyl-5 cyclohexanone

hydroxymethylene-2 methyl-5 cyclohexanone

t-butyldimethylsilyloxymethyl-2 methyl-5 cyclohexanone trans

3-Methylcyclohexanone