(2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-pentanenitrile

Base Information

• Chemical Name: (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-pentanenitrile
• CAS No.: 197153-82-5
• Molecular Formula: C₃₄H₄₇NO₄Si
• Molecular Weight: 561.837

Synonyms:

Chemical Property of (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-pentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-pentanenitrile

There total 6 articles about (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) + (S)-4-Hydroxy-2-hydroxymethyl-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-pentanenitrile → (3S,5S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxymethyl)-dihydro-furan-2-one + (3R,5S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxymethyl)-dihydro-furan-2-one + (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-pentanenitrile (197153-82-5) + (2R,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-pentanenitrile (197153-80-3)

Guidance literature:

With 1H-imidazole; In pyridine; N,N-dimethyl-formamide; at 0 ℃; for 3h; Yield given. Further byproducts given;

DOI:10.1007/bf00806859

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) + (S)-4-Hydroxy-2-hydroxymethyl-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-pentanenitrile → (S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-pentanenitrile + (3R,5S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxymethyl)-dihydro-furan-2-one + (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-pentanenitrile (197153-82-5) + (2R,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-pentanenitrile (197153-80-3)

Guidance literature:

With 1H-imidazole; In pyridine; N,N-dimethyl-formamide; at 0 ℃; for 3h; Further byproducts given;

DOI:10.1007/bf00806859

Reference yield:

(2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran] (108031-80-7) → (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-pentanenitrile (197153-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / Ph₃P*HBr / CH₂Cl₂ / 6 h

2: 77 percent / NaBH₄ / propan-2-ol / 3.5 h / Ambient temperature

3: 3.27 g / imidazole / dimethylformamide; pyridine / 3 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; triphenylphosphine hydrobromide; In pyridine; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1007/bf00806859

upstream raw materials:

tert-butylchlorodiphenylsilane

(2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran]

(S)-5-Hydroxymethyl-2-oxo-tetrahydro-furan-3-carbonitrile

2-Cyano-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propionic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 197153-82-5 (2S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-((1R,2R,4R,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-pentanenitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send