1-carbethoxy-1-phenylmethyl phosphorodichloridite

Base Information

• Chemical Name: 1-carbethoxy-1-phenylmethyl phosphorodichloridite
• CAS No.: 884488-78-2
• Molecular Formula: C₁₀H₁₁Cl₂O₃P
• Molecular Weight: 281.075
• Mol file: 884488-78-2.mol

Synonyms:

Chemical Property of 1-carbethoxy-1-phenylmethyl phosphorodichloridite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-carbethoxy-1-phenylmethyl phosphorodichloridite

There total 1 articles about 1-carbethoxy-1-phenylmethyl phosphorodichloridite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

hydroxy-phenyl-acetic acid ethyl ester (774-40-3,4358-88-7) → 1-carbethoxy-1-phenylmethyl phosphorodichloridite (884488-78-2)

Guidance literature:

With phosphorus trichloride; for 6h; cooling;

DOI:10.1055/s-2006-926324

Reference yield:

1-carbethoxy-1-phenylmethyl phosphorodichloridite (884488-78-2) → ethyl 2-[({1-[(benzyloxycarbonyl)amino]phenylmethyl}hydroxyphosphoryl)oxy]phenylacetate

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 6 h / 20 °C

2: H₂O / benzene / 2 h

With water; In benzene; 1: Mannich reaction;

DOI:10.1055/s-2006-926324

Reference yield:

1-carbethoxy-1-phenylmethyl phosphorodichloridite (884488-78-2) → ethyl 2-[({1-[(benzyloxycarbonyl)amino]-(4-methoxyphenyl)methyl}hydroxyphosphoryl)oxy]phenylacetate

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 6 h / 20 °C

2: H₂O / benzene / 2 h

With water; In benzene; 1: Mannich reaction;

DOI:10.1055/s-2006-926324

upstream raw materials:

hydroxy-phenyl-acetic acid ethyl ester