N-(N²-trityl-L-asparaginyl)-L-leucine

Base Information

• Chemical Name: N-(N²-trityl-L-asparaginyl)-L-leucine
• CAS No.: 106409-04-5
• Molecular Formula: C₂₉H₃₃N₃O₄
• Molecular Weight: 487.599
• Mol file: 106409-04-5.mol

Synonyms:

Chemical Property of N-(N²-trityl-L-asparaginyl)-L-leucine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N²-trityl-L-asparaginyl)-L-leucine

There total 4 articles about N-(N²-trityl-L-asparaginyl)-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-trityl dibenzyl L-aspartate (57818-19-6) → N-(N2-trityl-L-asparaginyl)-L-leucine (106409-04-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous KOH; dioxane / beim Behandeln des Reaktionsprodukts mit Dicyclohexylcarbodiimid und NH₃ in CH₂Cl₂

2: palladium; triethylamine; ethanol / Hydrogenation

3: dicyclohexylcarbodiimide; CH₂Cl₂ / beim Hydrieren des Reaktionsprodukts an Palladium in Diaethyamin enthaltendem Aethanol

With 1,4-dioxane; potassium hydroxide; ethanol; dichloromethane; palladium; triethylamine; dicyclohexyl-carbodiimide;

Reference yield:

N2-trityl-L-asparagine trityl ester (3226-95-7) → N-(N2-trityl-L-asparaginyl)-L-leucine (106409-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium; triethylamine; ethanol / Hydrogenation

2: dicyclohexylcarbodiimide; CH₂Cl₂ / beim Hydrieren des Reaktionsprodukts an Palladium in Diaethyamin enthaltendem Aethanol

With ethanol; dichloromethane; palladium; triethylamine; dicyclohexyl-carbodiimide;

Reference yield:

N2-trityl-L-asparagine benzyl ester (97151-62-7) → N-(N2-trityl-L-asparaginyl)-L-leucine (106409-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium; triethylamine; ethanol / Hydrogenation

2: dicyclohexylcarbodiimide; CH₂Cl₂ / beim Hydrieren des Reaktionsprodukts an Palladium in Diaethyamin enthaltendem Aethanol

With ethanol; dichloromethane; palladium; triethylamine; dicyclohexyl-carbodiimide;

upstream raw materials:

N-Trt-Asn

L-leucine benzyl ester hydrochloride

N²-trityl-L-asparagine benzyl ester

N-trityl dibenzyl L-aspartate

Downstream raw materials:

L-Asparaginyl-L-leucin