Phosphoric acid (4aR,6R,7R,7aR)-6-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-di-tert-butyl-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-7-yl ester bis-(2-cyano-1,1-dimethyl-ethyl) ester

Base Information

• Chemical Name: Phosphoric acid (4aR,6R,7R,7aR)-6-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-di-tert-butyl-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-7-yl ester bis-(2-cyano-1,1-dimethyl-ethyl) ester
• CAS No.: 176663-97-1
• Molecular Formula: C₃₄H₄₇N₄O₁₀PSi
• Molecular Weight: 730.827
• Mol file: 176663-97-1.mol

Synonyms:

Chemical Property of Phosphoric acid (4aR,6R,7R,7aR)-6-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-di-tert-butyl-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-7-yl ester bis-(2-cyano-1,1-dimethyl-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (4aR,6R,7R,7aR)-6-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-di-tert-butyl-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-7-yl ester bis-(2-cyano-1,1-dimethyl-ethyl) ester

There total 4 articles about Phosphoric acid (4aR,6R,7R,7aR)-6-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-di-tert-butyl-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-7-yl ester bis-(2-cyano-1,1-dimethyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-3-methylbutyronitrile (13635-04-6) → Phosphoric acid (4aR,6R,7R,7aR)-6-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-di-tert-butyl-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-7-yl ester bis-(2-cyano-1,1-dimethyl-ethyl) ester (176663-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / diethyl ether / 3.5 h / Ambient temperature

2: 1.) 1H-tetrazole, 2.) t-BuOOH / 1.) CH₂Cl₂, room temperature, 2 h, 2.) room temperature, 10 min

With 1H-tetrazole; tert.-butylhydroperoxide; triethylamine; In diethyl ether;

DOI:10.1021/jo952073k

Reference yield:

Di-tert-butyldichlorosilane (18395-90-9) → Phosphoric acid (4aR,6R,7R,7aR)-6-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-di-tert-butyl-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-7-yl ester bis-(2-cyano-1,1-dimethyl-ethyl) ester (176663-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / AgNO₃ / dimethylformamide / 0.5 h / Ambient temperature

2: 1.) 1H-tetrazole, 2.) t-BuOOH / 1.) CH₂Cl₂, room temperature, 2 h, 2.) room temperature, 10 min

With 1H-tetrazole; tert.-butylhydroperoxide; silver nitrate; In N,N-dimethyl-formamide;

DOI:10.1021/jo952073k

Reference yield:

N3-benzoyluridine (86988-30-9) → Phosphoric acid (4aR,6R,7R,7aR)-6-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,2-di-tert-butyl-tetrahydro-furo[3,2-d][1,3,2]dioxasilin-7-yl ester bis-(2-cyano-1,1-dimethyl-ethyl) ester (176663-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / AgNO₃ / dimethylformamide / 0.5 h / Ambient temperature

2: 1.) 1H-tetrazole, 2.) t-BuOOH / 1.) CH₂Cl₂, room temperature, 2 h, 2.) room temperature, 10 min

With 1H-tetrazole; tert.-butylhydroperoxide; silver nitrate; In N,N-dimethyl-formamide;

DOI:10.1021/jo952073k

upstream raw materials:

N³-benzoyl-3',5'-O-(di-tert-butylsilanediyl)uridine

bis(2-cyano-1,1-dimethylethyl) N,N-diethylphosphoramidite

3-hydroxy-3-methylbutyronitrile

Di-tert-butyldichlorosilane

Downstream raw materials:

Phosphoric acid (2R,3R,4R,5R)-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester bis-(2-cyano-1,1-dimethyl-ethyl) ester