{4-[3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxo-propionylamino]benzyl}isopropylcarbamic acid tert-butyl ester

Base Information

• Chemical Name: {4-[3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxo-propionylamino]benzyl}isopropylcarbamic acid tert-butyl ester
• CAS No.: 838823-86-2
• Molecular Formula: C₃₂H₃₈N₂O₆
• Molecular Weight: 546.664
• Mol file: 838823-86-2.mol

Synonyms:

Chemical Property of {4-[3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxo-propionylamino]benzyl}isopropylcarbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxo-propionylamino]benzyl}isopropylcarbamic acid tert-butyl ester

There total 2 articles about {4-[3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxo-propionylamino]benzyl}isopropylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxopropionic acid methyl ester (838823-65-7) + 4-(N-isopropyl-N-tert-butoxycarbonyl-aminomethyl)-aniline → {4-[3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxo-propionylamino]benzyl}isopropylcarbamic acid tert-butyl ester (838823-86-2)

Guidance literature:

In xylene; at 150 ℃; for 6h;

DOI:10.1021/jm0704604

Reference yield:

→ {4-[3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxo-propionylamino]benzyl}isopropylcarbamic acid tert-butyl ester (838823-86-2)

Guidance literature:

Reference yield:

{4-[3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxo-propionylamino]benzyl}isopropylcarbamic acid tert-butyl ester (838823-86-2) → {4-[5-(2',4'-dimethoxybiphenyl-4-yl)-1H-pyrazol-3-ylamino]benzyl}isopropylcarbamic acid tert-butyl ester

Guidance literature:

{4-[3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxo-propionylamino]benzyl}isopropylcarbamic acid tert-butyl ester; With Lawessons reagent; In tetrahydrofuran; for 3h; Heating;

With hydrazine hydrate; In ethanol; for 48h; Further stages.; Heating;

DOI:10.1021/jm0704604

upstream raw materials:

3-(2',4'-dimethoxybiphenyl-4-yl)-3-oxopropionic acid methyl ester