Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester

Base Information

• Chemical Name: Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester
• CAS No.: 88557-39-5
• Molecular Formula: C₂₀H₂₈O₆
• Molecular Weight: 364.439
• Mol file: 88557-39-5.mol

Synonyms:

Chemical Property of Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester

There total 13 articles about Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((4R,5S)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)methanol (88557-31-7) → Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester (88557-39-5)

Guidance literature:

Multi-step reaction with 7 steps

1: NaH

2: Amberlyst 15

4: H₂ / Pd/BaSO₄

5: 77.6 percent / oxidizing agent

7: aq. AcOH

With Amberlyst 15; oxidizing agent; hydrogen; sodium hydride; acetic acid; Pd-BaSO₄;

DOI:10.1271/bbb1961.47.2411

Reference yield:

2,2-Dimethyl-propionic acid (2R,3S)-2,3-dihydroxy-octyl ester (106031-55-4) → Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester (88557-39-5)

Guidance literature:

Multi-step reaction with 9 steps

2: KOH

3: NaH

4: Amberlyst 15

6: H₂ / Pd/BaSO₄

7: 77.6 percent / oxidizing agent

9: aq. AcOH

With potassium hydroxide; Amberlyst 15; oxidizing agent; hydrogen; sodium hydride; acetic acid; Pd-BaSO₄;

DOI:10.1271/bbb1961.47.2411

Reference yield:

(2R,3S)-octane-1,2,3-triol (88557-30-6) → Acetic acid (1R,2S)-2-acetoxy-1-[(E)-2-(3-hydroxy-2-hydroxymethyl-phenyl)-vinyl]-heptyl ester (88557-39-5)

Guidance literature:

Multi-step reaction with 10 steps

3: KOH

4: NaH

5: Amberlyst 15

7: H₂ / Pd/BaSO₄

8: 77.6 percent / oxidizing agent

10: aq. AcOH

With potassium hydroxide; Amberlyst 15; oxidizing agent; hydrogen; sodium hydride; acetic acid; Pd-BaSO₄;

DOI:10.1271/bbb1961.47.2411

upstream raw materials:

(3-hydroxy-1,2-phenylene)dimethanol

((4R,5S)-2,2-dimethyl-5-pentyl-1,3-dioxolan-4-yl)methanol

(2R,3S)-octane-1,2,3-triol

2,2-Dimethyl-propionic acid (2R,3S)-2,3-dihydroxy-octyl ester

Downstream raw materials:

dechloromonilidiol

dechloromonilidiol diacetate

Refernces