5-Bromo-2-phenyl-3-aminoindole

Base Information

• Chemical Name: 5-Bromo-2-phenyl-3-aminoindole
• CAS No.: 83515-08-6
• Molecular Formula: C₁₄H₁₁BrN₂
• Molecular Weight: 287.159
• Mol file: 83515-08-6.mol

Synonyms:

Chemical Property of 5-Bromo-2-phenyl-3-aminoindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Bromo-2-phenyl-3-aminoindole

There total 6 articles about 5-Bromo-2-phenyl-3-aminoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-Bromo-2-phenyl-3-nitrosoindole (83515-07-5) → 5-Bromo-2-phenyl-3-aminoindole (83515-08-6)

Guidance literature:

With sodium hydroxide; sodium dithionite; In ethanol; Heating;

Reference yield:

(E)-2-(benzylideneamino)-5-bromobenzonitrile → 5-Bromo-2-phenyl-3-aminoindole (83515-08-6)

Guidance literature:

With bis(cyclopentadienyl)titanium dichloride; manganese; chloro-trimethyl-silane; triethylamine hydrochloride; In tetrahydrofuran; at 35 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201702310

Reference yield:

2-amino-5-bromobenzonitrile (39263-32-6) → 5-Bromo-2-phenyl-3-aminoindole (83515-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Schlenk technique; Inert atmosphere; Molecular sieve; Reflux

2: triethylamine hydrochloride; manganese; bis(cyclopentadienyl)titanium dichloride; chloro-trimethyl-silane / tetrahydrofuran / 24 h / 35 °C / Schlenk technique; Inert atmosphere; Sealed tube

With bis(cyclopentadienyl)titanium dichloride; manganese; chloro-trimethyl-silane; triethylamine hydrochloride; In tetrahydrofuran; toluene;

DOI:10.1002/anie.201702310

upstream raw materials:

5-Bromo-2-phenyl-3-nitrosoindole

5-bromo-2-phenylindole

anthranilic acid nitrile

2-amino-5-bromobenzonitrile

Downstream raw materials:

5-Bromo-2-phenyl-3-iminoindole

5-bromo-2-phenyl-3H-indol-3-one

5-Bromo-2-phenylindol-3-one semicarbazone

5-Bromo-2-phenylindol-3-one thiosemicarbazone