(E)-3-(3-bromo-4-methoxy-phenyl)-acrylic acid azide

Base Information

• Chemical Name: (E)-3-(3-bromo-4-methoxy-phenyl)-acrylic acid azide
• CAS No.: 758710-72-4
• Molecular Formula: C₁₀H₈BrN₃O₂
• Molecular Weight: 282.096
• Mol file: 758710-72-4.mol

Synonyms:

Chemical Property of (E)-3-(3-bromo-4-methoxy-phenyl)-acrylic acid azide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(3-bromo-4-methoxy-phenyl)-acrylic acid azide

There total 1 articles about (E)-3-(3-bromo-4-methoxy-phenyl)-acrylic acid azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(3-bromo-4-methoxy-phenyl)prop-2-enoyl chloride → (E)-3-(3-bromo-4-methoxy-phenyl)-acrylic acid azide (758710-72-4)

Guidance literature:

With sodium azide; In water; at 0 ℃; for 5h;

DOI:10.1016/S0040-4039(01)01780-4

Reference yield:

(E)-3-(3-bromo-4-methoxy-phenyl)-acrylic acid azide (758710-72-4) → 2-Bromo-4-((E)-2-isocyanato-vinyl)-1-methoxy-benzene

Guidance literature:

In toluene; at 110 ℃;

DOI:10.1016/S0040-4039(01)01780-4

Reference yield:

(E)-3-(3-bromo-4-methoxy-phenyl)-acrylic acid azide (758710-72-4) → [2-(3-bromo-4-methoxyphenyl)ethyl]carbamic acid ethyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 110 °C

2: 80 °C

3: 99 percent / Et₃SiH / trifluoroacetic acid / 0.5 h / -10 °C

With triethylsilane; In toluene; trifluoroacetic acid; 1: Curtius rearrangement;

DOI:10.1016/S0040-4039(01)01780-4