N-tosyl-1-(3,4-epoxybutyl)cyclohexylamine

Base Information

• Chemical Name: N-tosyl-1-(3,4-epoxybutyl)cyclohexylamine
• CAS No.: 134786-17-7
• Molecular Formula: C₁₇H₂₅NO₃S
• Molecular Weight: 323.456
• Mol file: 134786-17-7.mol

Synonyms:

Chemical Property of N-tosyl-1-(3,4-epoxybutyl)cyclohexylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tosyl-1-(3,4-epoxybutyl)cyclohexylamine

There total 6 articles about N-tosyl-1-(3,4-epoxybutyl)cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl cyclohexylcarboxylate (4630-82-4) → N-tosyl-1-(3,4-epoxybutyl)cyclohexylamine (134786-17-7)

Guidance literature:

Multi-step reaction with 6 steps

1: iPr₂NLi / tetrahydrofuran / -78 °C

2: 15percent ethanolic KOH / Heating

3: 1) triethylamine, diphenyl azidophosphate, 2) a) dibutyltin diacetate, b) aq. NaOH / 1) benzene, reflux, 3 h, 2) a) reflux, 48 h, b) ethanol, reflux, 0.5 h

4: 63 percent / KOH / H₂O; ethane-1,2-diol / 18 h / 140 °C

5: 75 percent / 25percent aq. NaOH / dimethylformamide; H₂O / 1 h / pH 12

6: 1) m-chloroperbenzoic acid, 2) potassium carbonate / 1) chloroform, room temperature, 2) 0 deg C, 2 h

With potassium hydroxide; sodium hydroxide; dibutyltin diacetate; diphenyl phosphoryl azide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; water; ethylene glycol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)96036-3

Reference yield:

1-(but-3-enyl)cyclohexylamine (134786-07-5) → N-tosyl-1-(3,4-epoxybutyl)cyclohexylamine (134786-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / 25percent aq. NaOH / dimethylformamide; H₂O / 1 h / pH 12

2: 1) m-chloroperbenzoic acid, 2) potassium carbonate / 1) chloroform, room temperature, 2) 0 deg C, 2 h

With sodium hydroxide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)96036-3

Reference yield:

acide 1-(but-3-enyl)cyclohexanecarboxylique (134820-88-5) → N-tosyl-1-(3,4-epoxybutyl)cyclohexylamine (134786-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) triethylamine, diphenyl azidophosphate, 2) a) dibutyltin diacetate, b) aq. NaOH / 1) benzene, reflux, 3 h, 2) a) reflux, 48 h, b) ethanol, reflux, 0.5 h

2: 63 percent / KOH / H₂O; ethane-1,2-diol / 18 h / 140 °C

3: 75 percent / 25percent aq. NaOH / dimethylformamide; H₂O / 1 h / pH 12

4: 1) m-chloroperbenzoic acid, 2) potassium carbonate / 1) chloroform, room temperature, 2) 0 deg C, 2 h

With potassium hydroxide; sodium hydroxide; dibutyltin diacetate; diphenyl phosphoryl azide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In water; ethylene glycol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)96036-3

upstream raw materials:

N-tosyl-1-(but-3-enyl)cyclohexylamine

methyl cyclohexylcarboxylate

1-(but-3-enyl)cyclohexylamine

acide 1-(but-3-enyl)cyclohexanecarboxylique

Downstream raw materials:

N-tosyl-1-azaspiro<4,5>decane-2-methanol

acide N-tosyl-1-azaspiro<4,5>decane-2-carboxylique