(2S,3S)-6-Oxo-2,3-diphenyl-spiro[4.5]decane-7-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,3S)-6-Oxo-2,3-diphenyl-spiro[4.5]decane-7-carboxylic acid methyl ester
CAS No.:125250-88-6
Molecular Formula:C₂₄H₂₆O₃
Molecular Weight:362.469
Hs Code.:

Synonyms:

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Chemical Property of (2S,3S)-6-Oxo-2,3-diphenyl-spiro[4.5]decane-7-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (2S,3S)-6-Oxo-2,3-diphenyl-spiro[4.5]decane-7-carboxylic acid methyl ester

There total 10 articles about (2S,3S)-6-Oxo-2,3-diphenyl-spiro[4.5]decane-7-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125250-87-5
methyl trans-3,4-diphenyl-1-(4-carbomethoxybutyl)cyclopentanecarboxylate

: 125250-88-6,125353-87-9
(2S,3S)-6-Oxo-2,3-diphenyl-spiro[4.5]decane-7-carboxylic acid methyl ester

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; -78 deg C to room temperature;
DOI:10.1021/jo00294a016

Reference yield:

: 103-36-6
ethyl 3-phenyl-2-propenoate

: 125250-88-6,125353-87-9
(2S,3S)-6-Oxo-2,3-diphenyl-spiro[4.5]decane-7-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: sodium / diethyl ether / 3 h / Heating

2: 20percent HBr / aq. ethanol / Heating

3: 92 percent / Zn dust, TiCl₄ / tetrahydrofuran / 2.5 h / Ambient temperature

4: 1.) BH₃*THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) THF, 0 deg C to room temperature, 2.) room temperature, 1 h

5: 95 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.33 h / -60 °C

6: Br₂, sodium bicarbonate buffer / H₂O

7: 1.) n-BuLi, diisopropylamine / 1.) THF, -60 deg C, 30 min, 2.) -60 to -15 deg C

8: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran

9: 1.) oxalyl chloride, DMSO, 2.) Br₂, NaHCO₃ buffer / 1.) CH₂Cl₂, 2.) H₂O

10: n-BuLi, diisopropylamine / tetrahydrofuran / -78 deg C to room temperature

With sodium hydroxide; n-butyllithium; borane-THF; oxalyl dichloride; NaHCO₃ buffer; sodium bicarbonate buffer; tetrabutyl ammonium fluoride; hydrogen bromide; dihydrogen peroxide; bromine; sodium; titanium tetrachloride; dimethyl sulfoxide; diisopropylamine; zinc; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jo00294a016

Reference yield:

: 7356-94-7
2,3-Diphenyl-5-oxo-cyclopentancarbonsaeureethylester

: 125250-88-6,125353-87-9
(2S,3S)-6-Oxo-2,3-diphenyl-spiro[4.5]decane-7-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 20percent HBr / aq. ethanol / Heating

2: 92 percent / Zn dust, TiCl₄ / tetrahydrofuran / 2.5 h / Ambient temperature

3: 1.) BH₃*THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) THF, 0 deg C to room temperature, 2.) room temperature, 1 h

4: 95 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 0.33 h / -60 °C

5: Br₂, sodium bicarbonate buffer / H₂O

6: 1.) n-BuLi, diisopropylamine / 1.) THF, -60 deg C, 30 min, 2.) -60 to -15 deg C

7: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran

8: 1.) oxalyl chloride, DMSO, 2.) Br₂, NaHCO₃ buffer / 1.) CH₂Cl₂, 2.) H₂O

9: n-BuLi, diisopropylamine / tetrahydrofuran / -78 deg C to room temperature

With sodium hydroxide; n-butyllithium; borane-THF; oxalyl dichloride; NaHCO₃ buffer; sodium bicarbonate buffer; tetrabutyl ammonium fluoride; hydrogen bromide; dihydrogen peroxide; bromine; titanium tetrachloride; dimethyl sulfoxide; diisopropylamine; zinc; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jo00294a016