C₄₁H₆₆N₁₀O₉S*ClH

Base Information

• Chemical Name: C₄₁H₆₆N₁₀O₉S*ClH
• CAS No.: 78221-66-6
• Molecular Formula: C₄₁H₆₆N₁₀O₉S*ClH
• Molecular Weight: 911.564
• Mol file: 78221-66-6.mol

Synonyms:

Chemical Property of C₄₁H₆₆N₁₀O₉S*ClH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₆₆N₁₀O₉S*ClH

There total 11 articles about C₄₁H₆₆N₁₀O₉S*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-nitrobenzenesulfenyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide (78221-65-5) → C41H66N10O9S*ClH (78221-66-6)

Guidance literature:

With hydrogenchloride; In diethyl ether; N,N-dimethyl-formamide; for 0.0666667h; Ambient temperature;

DOI:10.1135/cccc19810286

Reference yield:

melanostatin (2002-44-0) → C41H66N10O9S*ClH (78221-66-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 86 percent / dicyclohexylcarbodiimide, hydroxybenzotriazole / dimethylformamide / 1) 0 deg C, 1 h; 2) room temp., 20 h

2: HBr / acetic acid / 0.5 h / Ambient temperature

3: 2.56 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

4: HCl / dimethylformamide; diethyl ether / 0.08 h / Ambient temperature

5: 1.8 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

6: HCl / diethyl ether; dimethylformamide / 0.07 h

7: 1 g / N-ethylpiperidine / dimethylformamide / 72 h / Ambient temperature

8: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In diethyl ether; acetic acid; N,N-dimethyl-formamide;

DOI:10.1135/cccc19810286

Reference yield:

S-(2,4,6-trimethylbenzyl)-L-cysteine (78221-55-3) → C41H66N10O9S*ClH (78221-66-6)

Guidance literature:

Multi-step reaction with 9 steps

1: 69 percent / NaOH / H₂O / 0.5 h / Ambient temperature

2: 86 percent / dicyclohexylcarbodiimide, hydroxybenzotriazole / dimethylformamide / 1) 0 deg C, 1 h; 2) room temp., 20 h

3: HBr / acetic acid / 0.5 h / Ambient temperature

4: 2.56 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

5: HCl / dimethylformamide; diethyl ether / 0.08 h / Ambient temperature

6: 1.8 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

7: HCl / diethyl ether; dimethylformamide / 0.07 h

8: 1 g / N-ethylpiperidine / dimethylformamide / 72 h / Ambient temperature

9: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In diethyl ether; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1135/cccc19810286

upstream raw materials:

o-nitrobenzenesulfenyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

melanostatin

S-(2,4,6-trimethylbenzyl)-L-cysteine

2-chloromethyl-1,3,5-trimethylbenzene

Downstream raw materials:

C₅₄H₈₃N₁₁O₁₁S*ClH

Refernces