1-{2-[4-(4-chlorophenyl)-6-fluoro-7-hydroxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}-3-[4-(trifluoromethoxy)phenyl]urea

Base Information

Chemical Name:1-{2-[4-(4-chlorophenyl)-6-fluoro-7-hydroxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}-3-[4-(trifluoromethoxy)phenyl]urea
CAS No.:1555698-00-4
Molecular Formula:C₃₀H₂₄ClF₄N₃O₃
Molecular Weight:585.985
Hs Code.:

Synonyms:

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Chemical Property of 1-{2-[4-(4-chlorophenyl)-6-fluoro-7-hydroxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}-3-[4-(trifluoromethoxy)phenyl]urea

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Technology Process of 1-{2-[4-(4-chlorophenyl)-6-fluoro-7-hydroxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}-3-[4-(trifluoromethoxy)phenyl]urea

There total 7 articles about 1-{2-[4-(4-chlorophenyl)-6-fluoro-7-hydroxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}-3-[4-(trifluoromethoxy)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1617505-25-5
C₃₁H₂₆ClF₄N₃O₃

: 1555698-00-4
1-{2-[4-(4-chlorophenyl)-6-fluoro-7-hydroxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}-3-[4-(trifluoromethoxy)phenyl]urea

Guidance literature:: C₃₁H₂₆ClF₄N₃O₃; With boron tribromide-dimethyl sulfide complex; In dichloromethane; at 85 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water; at 65 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm5006226

Reference yield:

: 1555701-66-0
4-bromo-6-fluoro-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

: 1555698-00-4
1-{2-[4-(4-chlorophenyl)-6-fluoro-7-hydroxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}-3-[4-(trifluoromethoxy)phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; ammonium chloride / methanol; ethyl acetate / 20 °C / Inert atmosphere

2.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / Dimethyl ether / 100 °C / Inert atmosphere; Sealed tube

4.1: boron tribromide-dimethyl sulfide complex / dichloromethane / 16 h / 85 °C / Inert atmosphere

4.2: 1 h / 65 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide-dimethyl sulfide complex; sodium carbonate; ammonium chloride; zinc; In methanol; Dimethyl ether; dichloromethane; ethyl acetate; 3.1: |Suzuki Coupling;
DOI:10.1021/jm5006226

Reference yield:

: 1617505-11-9
C₂₅H₂₂BrF₄N₃O₃

: 1555698-00-4
1-{2-[4-(4-chlorophenyl)-6-fluoro-7-hydroxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}-3-[4-(trifluoromethoxy)phenyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / Dimethyl ether / 100 °C / Inert atmosphere; Sealed tube

2.1: boron tribromide-dimethyl sulfide complex / dichloromethane / 16 h / 85 °C / Inert atmosphere

2.2: 1 h / 65 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide-dimethyl sulfide complex; sodium carbonate; In Dimethyl ether; dichloromethane; 1.1: |Suzuki Coupling;
DOI:10.1021/jm5006226