Technology Process of N3-(p-methoxybenzyl)-thymin-1-ylacetyl fluoride
There total 3 articles about N3-(p-methoxybenzyl)-thymin-1-ylacetyl fluoride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / aq.NaOH / 0.5 h / Heating
2: 90 percent / pyridine; cyanuric fluoride / CH2Cl2 / 3 h
With
pyridine; sodium hydroxide; trifluoro-[1,3,5]triazine;
In
dichloromethane;
DOI:10.1021/ol016822y
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 79 percent / K2CO3 / dimethylformamide / 18 h / 20 °C
2.1: NaH / dimethylformamide / 0.17 h / cooling
2.2: 50 percent / dimethylformamide / 3 h / 20 °C
3.1: 99 percent / aq.NaOH / 0.5 h / Heating
4.1: 90 percent / pyridine; cyanuric fluoride / CH2Cl2 / 3 h
With
pyridine; sodium hydroxide; trifluoro-[1,3,5]triazine; sodium hydride; potassium carbonate;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol016822y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaH / dimethylformamide / 0.17 h / cooling
1.2: 50 percent / dimethylformamide / 3 h / 20 °C
2.1: 99 percent / aq.NaOH / 0.5 h / Heating
3.1: 90 percent / pyridine; cyanuric fluoride / CH2Cl2 / 3 h
With
pyridine; sodium hydroxide; trifluoro-[1,3,5]triazine; sodium hydride;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol016822y
