(E)-2-chloro-4-cinnamylphenol

Base Information

• Chemical Name: (E)-2-chloro-4-cinnamylphenol
• CAS No.: 1616917-81-7
• Molecular Formula: C₁₅H₁₃ClO
• Molecular Weight: 244.721
• Mol file: 1616917-81-7.mol

Synonyms:

Chemical Property of (E)-2-chloro-4-cinnamylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-chloro-4-cinnamylphenol

There total 2 articles about (E)-2-chloro-4-cinnamylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

C21H24BClO3 (1616917-74-8) → (E)-2-chloro-4-cinnamylphenol (1616917-81-7) + (E,E)-2-chloro-4-cinnamyl-1-(cinnamyloxy)benzene (1616917-82-8)

Guidance literature:

With C₁₄H₁₆N₆; palladium diacetate; calcium hydroxide; In N,N-dimethyl acetamide; water; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo501235w

Reference yield:

2‐chloro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenol (629658-06-6) + Cinnamyl bromide (4392-24-9) → (E)-2-chloro-4-cinnamylphenol (1616917-81-7) + (E,E)-2-chloro-4-cinnamyl-1-(cinnamyloxy)benzene (1616917-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 24 h / 50 °C

2: palladium diacetate; calcium hydroxide; C₁₄H₁₆N₆ / N,N-dimethyl acetamide; water / 24 h / 50 °C / Inert atmosphere

With C₁₄H₁₆N₆; palladium diacetate; potassium carbonate; calcium hydroxide; In N,N-dimethyl acetamide; water; acetone;

DOI:10.1021/jo501235w

upstream raw materials:

C₂₁H₂₄BClO₃

2‐chloro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenol

Cinnamyl bromide