Technology Process of 13-<(E)-2-<(phenylmethyl)trithio>ethylidene>spirotrideca-4,9-diene-2,6-diyne-11,2'-<1,3>dioxolane>-1,8-diol
There total 11 articles about 13-<(E)-2-<(phenylmethyl)trithio>ethylidene>spirotrideca-4,9-diene-2,6-diyne-11,2'-<1,3>dioxolane>-1,8-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: periodic acid dihydrate / tetrahydrofuran / 0.08 h
2: dicyclohexylcarbodiimide / tetrahydrofuran / 1.5 h / Ambient temperature
3: lithium bromide, triethylamine / tetrahydrofuran / 3 h / Ambient temperature
4: diisobutylaluminum hydride / CH2Cl2; cyclohexane / 0.33 h / -78 °C
5: sodium borohydride, water / methanol / 0.75 h / 0 °C
6: 52 percent / diisopropyl azodicarboxylate, triphenylphosphine, thiolacetic acid / tetrahydrofuran / 1 h / 0 °C
7: 1.0 M diisobutylaluminum hydride / CH2Cl2; cyclohexane / 0.5 h / -78 °C
8: CH2Cl2; tetrahydrofuran / 20 h / -20 °C
With
sodium tetrahydroborate; di-isopropyl azodicarboxylate; water; diisobutylaluminium hydride; periodic acid; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; tiolacetic acid; lithium bromide;
In
tetrahydrofuran; methanol; dichloromethane; cyclohexane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: dicyclohexylcarbodiimide / tetrahydrofuran / 1.5 h / Ambient temperature
2: lithium bromide, triethylamine / tetrahydrofuran / 3 h / Ambient temperature
3: diisobutylaluminum hydride / CH2Cl2; cyclohexane / 0.33 h / -78 °C
4: sodium borohydride, water / methanol / 0.75 h / 0 °C
5: 52 percent / diisopropyl azodicarboxylate, triphenylphosphine, thiolacetic acid / tetrahydrofuran / 1 h / 0 °C
6: 1.0 M diisobutylaluminum hydride / CH2Cl2; cyclohexane / 0.5 h / -78 °C
7: CH2Cl2; tetrahydrofuran / 20 h / -20 °C
With
sodium tetrahydroborate; di-isopropyl azodicarboxylate; water; diisobutylaluminium hydride; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; tiolacetic acid; lithium bromide;
In
tetrahydrofuran; methanol; dichloromethane; cyclohexane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 52 percent / diisopropyl azodicarboxylate, triphenylphosphine, thiolacetic acid / tetrahydrofuran / 1 h / 0 °C
2: 1.0 M diisobutylaluminum hydride / CH2Cl2; cyclohexane / 0.5 h / -78 °C
3: CH2Cl2; tetrahydrofuran / 20 h / -20 °C
With
di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; tiolacetic acid;
In
tetrahydrofuran; dichloromethane; cyclohexane;
