1-Fluoro-3-[(4-methylphenyl)sulfanyl]propan-2-one

Base Information

Chemical Name:1-Fluoro-3-[(4-methylphenyl)sulfanyl]propan-2-one
CAS No.:105984-89-2
Molecular Formula:C10H11FOS
Molecular Weight:198.261
Hs Code.:
DSSTox Substance ID:DTXSID20545261
Wikidata:Q82422700

Synonyms:105984-89-2;1-Fluoro-3-[(4-methylphenyl)sulfanyl]propan-2-one;DTXSID20545261

Suppliers and Price of 1-Fluoro-3-[(4-methylphenyl)sulfanyl]propan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Fluoro-3-[(4-methylphenyl)sulfanyl]propan-2-one

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:198.05146431
Heavy Atom Count:13
Complexity:164

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)SCC(=O)CF

Technology Process of 1-Fluoro-3-[(4-methylphenyl)sulfanyl]propan-2-one

There total 2 articles about 1-Fluoro-3-[(4-methylphenyl)sulfanyl]propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 105984-80-3
(+)-(R)-1-fluoro-3-<(4-methylphenyl)sulfinyl>-2-propanone

: 105984-89-2
3-Fluoro-1-(4-methylphenylthio)-2-propanone

Guidance literature:: With trifluoroacetic anhydride; sodium iodide; In acetone; at -40 ℃; for 0.0833333h;
DOI:10.1055/s-1986-31714

Reference yield:

: 1519-39-7
(R)-methyl p-tolyl sulfoxide

: 105984-89-2
3-Fluoro-1-(4-methylphenylthio)-2-propanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) diisopropylamine, butyl lithium / THF, hexane, 1.) 3 min., -75 deg C, 2.) 5 min., -75 deg C

2: 88 percent / sodium iodide, trifluoroacetic anhydride / acetone / 0.08 h / -40 °C

With n-butyllithium; diisopropylamine; trifluoroacetic anhydride; sodium iodide; In acetone;
DOI:10.1055/s-1986-31714