[(2S,5R,6S)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Base Information

Chemical Name:[(2S,5R,6S)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester
CAS No.:1026371-85-6
Molecular Formula:C₃₆H₄₁N₂O₇P
Molecular Weight:644.704
Hs Code.:

[(2S,5R,6S)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

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Chemical Property of [(2S,5R,6S)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

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Technology Process of [(2S,5R,6S)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

There total 7 articles about [(2S,5R,6S)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026490-73-2
[(2S,5R,6S)-5-(3-Benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

: 1026371-85-6
[(2S,5R,6S)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Guidance literature:: With ammonia; In methanol; for 16h; Ambient temperature;
DOI:10.1021/jm950788+

Reference yield:

: 116-17-6
triisopropyl phosphite

: 1026371-85-6
[(2S,5R,6S)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / BF₃*Et₂O / toluene / 4 h / 100 °C

2: NH₃ / methanol / 6 h / Ambient temperature

3: 46 percent / pyridine / toluene / 24 h / Ambient temperature

4: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 0 - 20 °C

5: NH₃ / methanol / 16 h / Ambient temperature

With pyridine; boron trifluoride diethyl etherate; ammonia; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm950788+

Reference yield:

: 76-83-5
trityl chloride

: 1026371-85-6
[(2S,5R,6S)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / pyridine / toluene / 24 h / Ambient temperature

2: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 0 - 20 °C

3: NH₃ / methanol / 16 h / Ambient temperature

With pyridine; ammonia; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm950788+