Technology Process of sodium 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate
There total 15 articles about sodium 7β-acetamido>-7α-formamido-3-<(1-methyl-1H-tetrazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; trifluoroacetic acid;
In
water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 98 percent / TFA / 0.5 h / Ambient temperature
2: sodium hydrogen carbonate / acetone; H2O / 5 h / 60 °C
3: 22 percent / CH2Cl2; dimethylformamide / 4 h / Ambient temperature
4: 74 percent / pyridine / CH2Cl2
5: 63 percent / TFA, sodium hydrogen carbonate / H2O
With
pyridine; sodium hydrogencarbonate; trifluoroacetic acid;
In
dichloromethane; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 97 percent / pyridine / CH2Cl2 / 0 °C
2: 85 percent / mercury(II) acetate, ammonia / dimethylformamide / -40 degC then allowed to warm to room temperature
3: 75 percent / pyridine / CH2Cl2
4: 45 percent / potassium dihydrogen phosphate, zinc / 6 h
5: 98 percent / TFA / 0.5 h / Ambient temperature
6: sodium hydrogen carbonate / acetone; H2O / 5 h / 60 °C
7: 22 percent / CH2Cl2; dimethylformamide / 4 h / Ambient temperature
8: 74 percent / pyridine / CH2Cl2
9: 63 percent / TFA, sodium hydrogen carbonate / H2O
With
pyridine; potassium dihydrogenphosphate; mercury(II) diacetate; ammonia; sodium hydrogencarbonate; trifluoroacetic acid; zinc;
In
dichloromethane; water; N,N-dimethyl-formamide; acetone;
