N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate

Base Information

Chemical Name:N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate
CAS No.:1055925-58-0
Molecular Formula:C₂HF₃O₂*C₃₀H₄₂N₁₀O
Molecular Weight:672.754
Hs Code.:

N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate

Synonyms:

Suppliers and Price of N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Useful:

Technology Process of N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate

There total 7 articles about N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055925-57-9
N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide

: 76-05-1
trifluoroacetic acid

: 1055925-58-0
N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate

Guidance literature:: In water; acetonitrile;

Reference yield:

: 1055927-13-3
1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclohexylhydrazinecarboxylate

: 1055925-58-0
N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 150 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C

4.1: water; acetonitrile

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.2: 70 °C

6.1: water; acetonitrile

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1055925-58-0
N'-{2-cyano-9-[3-(dimethylamino)propyl]-9H-purin-6-yl}-N'-cyclohexyl-4-[(4-methyl-1-piperazinyl)methyl]benzohydrazide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C

2.1: water; acetonitrile

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.2: 70 °C

4.1: water; acetonitrile

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;