(2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

Base Information

Chemical Name:(2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate
CAS No.:111761-71-8
Molecular Formula:C₂₄H₂₃N₃O₅S
Molecular Weight:465.53
Hs Code.:

(2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro<imidazolidine-2,6'-penam>-3'-carboxylate

Synonyms:

Suppliers and Price of (2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

There total 11 articles about (2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 111761-70-7,111821-12-6,111821-13-7,111821-14-8
(2R,3'S,5S,5'R)-benzyl 2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

: 2258-42-6
formyl acetic anhydride

: 111761-71-8,111821-15-9
(2R,3'S,5S,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

Guidance literature:: With pyridine; In dichloromethane; 45 min, RT, 1 h, RT, 2.5 h RT;
DOI:10.1039/P19870000635

Reference yield:

: 40514-98-5
(6S)-benzyl 6-amino-6-(methylthio)penicillanate

: 111761-71-8,111821-15-9
(2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / triethylamine / tetrahydrofuran / 0.5 h / Ambient temperature

2: 56 percent / NH₄Cl, Zn powder / tetrahydrofuran; methanol / 0.5 h / Ambient temperature

3: 30 percent / mercuric acetate / tetrahydrofuran / 0.25 h / 0 - 5 °C

4: 76 percent / pyridine / CH₂Cl₂ / 45 min, RT, 1 h, RT

With pyridine; mercury(II) diacetate; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/P19870000635

Reference yield:

: 29125-25-5,3380-95-8
(R)-2-azido-2-phenylacetic acid

: 111761-71-8,111821-15-9
(2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, dry DMF / CH₂Cl₂ / 1 h / Ambient temperature

2: 92 percent / triethylamine / tetrahydrofuran / 0.5 h / Ambient temperature

3: 56 percent / NH₄Cl, Zn powder / tetrahydrofuran; methanol / 0.5 h / Ambient temperature

4: 30 percent / mercuric acetate / tetrahydrofuran / 0.25 h / 0 - 5 °C

5: 76 percent / pyridine / CH₂Cl₂ / 45 min, RT, 1 h, RT

With pyridine; oxalyl dichloride; mercury(II) diacetate; ammonium chloride; triethylamine; N,N-dimethyl-formamide; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/P19870000635