Technology Process of KMI-1880
There total 13 articles about KMI-1880 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: thionyl chloride
2: diethyl ether
3: sulfuric acid; acetic acid
4: diethylamine / N,N-dimethyl-formamide
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide
6: hydrogenchloride / 1,4-dioxane
7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide
8: diethylamine / 1,4-dioxane
9: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide
10: hydrogenchloride / 1,4-dioxane
With
hydrogenchloride; thionyl chloride; sulfuric acid; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine;
In
1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
3: Ritter reaction;
DOI:10.1016/j.bmcl.2011.11.102
- Guidance literature:
-
Multi-step reaction with 9 steps
1: pyridine; trifluoroacetic anhydride / tetrahydrofuran
2: sulfuric acid; acetic acid
3: diethylamine / N,N-dimethyl-formamide
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide
5: hydrogenchloride / 1,4-dioxane
6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide
7: diethylamine / 1,4-dioxane
8: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide
9: hydrogenchloride / 1,4-dioxane
With
pyridine; hydrogenchloride; sulfuric acid; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
2: Ritter reaction;
DOI:10.1016/j.bmcl.2011.11.102
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sulfuric acid; acetic acid
2: diethylamine / N,N-dimethyl-formamide
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide
4: hydrogenchloride / 1,4-dioxane
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide
6: diethylamine / 1,4-dioxane
7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide
8: hydrogenchloride / 1,4-dioxane
With
hydrogenchloride; sulfuric acid; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine;
In
1,4-dioxane; N,N-dimethyl-formamide;
1: Ritter reaction;
DOI:10.1016/j.bmcl.2011.11.102
