Benzophenone, 2-hydroxy-4'-methoxy-

Base Information

• Chemical Name: Benzophenone, 2-hydroxy-4'-methoxy-
• CAS No.: 18733-07-8
• Molecular Formula: C14H12 O3
• Molecular Weight: 228.247
• Hs Code.: 2914509090
• DSSTox Substance ID: DTXSID30172042
• Nikkaji Number: J109.982E
• Wikidata: Q83042186
• Mol file: 18733-07-8.mol

Synonyms:18733-07-8;Benzophenone, 2-hydroxy-4'-methoxy-;(2-hydroxyphenyl)-(4-methoxyphenyl)methanone;(2-Hydroxyphenyl)(4-methoxyphenyl)methanone;2-hydroxy-4'-methoxybenzophenone;Methanone, (2-hydroxyphenyl)(4-methoxyphenyl)-;SCHEMBL231448;DTXSID30172042;2-hydroxy-4'-methoxy-benzophenone;FT-0727586;(2-Hydroxyphenyl)(4-methoxyphenyl)methanone #

Chemical Property of Benzophenone, 2-hydroxy-4'-methoxy-

Chemical Property:

• Vapor Pressure: 1.05E-05mmHg at 25°C
• Boiling Point: 360.8°Cat760mmHg
• Flash Point: 136.1°C
• PSA: 46.53000
• Density: 1.201g/cm³
• LogP: 2.63180
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 228.078644241
• Heavy Atom Count: 17
• Complexity: 256

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=CC=CC=C2O

Technology Process of Benzophenone, 2-hydroxy-4'-methoxy-

There total 34 articles about Benzophenone, 2-hydroxy-4'-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-hydroxyphenyl boronic acid (89466-08-0) + 4-methoxybenzonitrile (874-90-8) → (2-hydroxyphenyl)(4-methoxyphenyl)methanone (18733-07-8)

Guidance literature:

With trifluorormethanesulfonic acid; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine; In water; at 90 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2014.11.009

Reference yield: 95.0%

para-iodoanisole (696-62-8) + salicylaldehyde (90-02-8) → (2-hydroxyphenyl)(4-methoxyphenyl)methanone (18733-07-8)

Guidance literature:

With dicarbonylacetylacetonato rhodium (I); sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700881

Reference yield: 91.0%

1-bromo-4-methoxy-benzene (104-92-7) + salicylaldehyde (90-02-8) → (2-hydroxyphenyl)(4-methoxyphenyl)methanone (18733-07-8)

Guidance literature:

With dicarbonylacetylacetonato rhodium (I); sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 120 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700881

upstream raw materials:

4-Methoxy-benzoic acid 2-iodo-phenyl ester

para-iodoanisole

salicylaldehyde

2-methyl-benzyl alcohol

Downstream raw materials:

2-(4-methoxybenzyl)phenol

3-(4'-methoxyphenyl)benzofuran

C₄₉H₅₀O₇

C₄₉H₄₈O₇

Refernces

• 1、 Dong, Shuang-Feng,Gao, Zhi-Yuan,He, Yu,Liu, Xu,Loh, Teck-Peng,Tian, Jie-Sheng,Wu, Peng. "Water-Tolerant ortho-Acylation of Phenols". supporting information. p. 6594 - 6598. Retrieved 2021/09/02.
• 2、 Prasanna Kumari, Subramaniyan,Suresh, Pavithira,Muthukumar, Vijayashree,Selva Ganesan, Subramaniapillai. "Cu/Ag mediated peroxide-free synthesis of benzoylated naphthol derivatives". supporting information. . Retrieved 2020/10/13.