Technology Process of H2N-(D)Glu(Bzl)-m(R,S)Arg(Mtr)-OH
There total 4 articles about H2N-(D)Glu(Bzl)-m(R,S)Arg(Mtr)-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2 / Pd/C / methanol; acetic acid / 12 h
2: 10 percent aq. Na2CO3 / dioxane / 72 h
3: 4 N NaOH / acetone / 2 h
4: N,N-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / CH2Cl2 / 18 h
5: trifluoroacetic acid, anisol / CH2Cl2 / 1 h
With
sodium hydroxide; hydrogen; sodium carbonate; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; acetic acid; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 10 percent aq. Na2CO3 / dioxane / 72 h
2: 4 N NaOH / acetone / 2 h
3: N,N-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / CH2Cl2 / 18 h
4: trifluoroacetic acid, anisol / CH2Cl2 / 1 h
With
sodium hydroxide; sodium carbonate; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 4 N NaOH / acetone / 2 h
2: N,N-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / CH2Cl2 / 18 h
3: trifluoroacetic acid, anisol / CH2Cl2 / 1 h
With
sodium hydroxide; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
dichloromethane; acetone;
